arXiv AI

PrinciplismQA: A Philosophy-Grounded Approach to Assessing LLM-Human Clinical Medical Ethics Alignment

arXiv:2508. 05132v3 Announce Type: replace-cross Abstract: As medical LLMs transition to clinical deployment, assessing their ethical reasoning capability becomes critical.

arXiv AI
Aug 18

ETHOS: Towards a Modular Ethics Framework for Clinical Multi-Agent Systems

arXiv:2608. 15424v1 Announce Type: cross Abstract: The rapid adoption of large language models has enabled the development of clinical multi-agent systems (MAS) capable of integrating multimodal patient data and supporting increasingly complex clinical decision-making.

By Rakesh Sharma, Sydney Pugh, Cameron Beeche, Pankhuri Singhal, Rachel Wu, Margaret Eby, Jeffrey Duda, James Gee, Kyra O'Brien, Hersh Sagreiya, Marina Serper, Victoria Gershuni, Angela Bradbury, Anurag Verma, Eric Eaton, Kevin B. Johnson, Walter Witschey
arXiv AI
Sep 4

Medical Reasoning in the Era of LLMs: A Systematic Review of Enhancement Techniques and Applications

The paper reviews how Large Language Models (LLMs) are being adapted for medical reasoning, moving beyond single-step answers to systems that can systematically, transparently, and verifiably reason. It introduces a taxonomy of enhancement techniques, split into training-time methods such as supervised fine‑tuning and reinforcement learning, and test-time methods like prompt engineering and multi‑agent systems. The review examines their application across text, image, and code modalities in key clinical areas—diagnosis, education, and treatment planning—and tracks the shift in evaluation benchmarks from simple accuracy to more nuanced assessments of reasoning quality and visual interpretability.

By Zizhan Ma, Wenxuan Wang, Meidan Ding, Shiyi Zheng, Shengyuan Liu, Jie Liu, Jiaming Ji, Linlin Shen, Yixuan Yuan, Wenting Chen
arXiv Computation and Language
Sep 1

CARE: Privacy-Compliant Agentic Reasoning with Evidence Discordance

The paper introduces MIMIC-DOS, a dataset derived from MIMIC-IV that focuses on ICU cases where patient symptoms and medical signs are discordant. It presents CARE, a privacy‑compliant multi‑stage agentic reasoning framework that uses a proprietary LLM to generate structured categories and transitions, while a local LLM performs evidence acquisition and decision‑making. In retrospective evaluations on MIMIC‑DOS, CARE outperforms other LLMs and agentic workflows, demonstrating stronger handling of conflicting clinical evidence while preserving patient privacy.

By Haochen Liu, Weien Li, Rui Song, Zeyu Li, Chun Jason Xue, Xiao-Yang Liu, Sam Nallaperuma-Herzberg, Xue Liu, Ye Yuan
arXiv AI
Aug 25

Teaching LLMs How ICU Physicians Approach Clinical Reasoning Through OMOP-Aligned Retrieval Improves Reasoning Across Clinical Domains

arXiv:2608.22622v1 Announce Type: cross Abstract: Clinical decision-making relies on identifying relevant patient information to guide diagnosis and treatment, a challenge that is especially difficul...

By Miguel Contreras, Scott Siegel, Subhash Nerella, Jessica Sena, Jiaqing Zhang, Heng Sun, Hruday Tej Akkaladevi, Peiyu Lu, Jordan Rosen, Sumit Kapoor, Sasank Desaraju, Grace R. Thompson, Jacob Purcell, Michael Petrauskis, Philip KW. Hong, Meghan Brennan, Sarah Chrabaszcz, Tierra Smith, Ronnie Ren, Michel S. Kabbash, Ceyhun Haziroglu, Rushi Patel, Gabriel Gomez, Charlotte Chaiklin, Randy Leung, Kenneth N. John, Whitman Wiggins, Philip Kayser, Vincent Bird, Maria Bruzzone, Tyler J. Loftus, Azra Bihorac, Parisa Rashidi
arXiv AI
Jul 28

OpenAIs HealthBench in Action: Evaluating an LLM-Based Medical Assistant on Realistic Clinical Queries

arXiv:2509. 02594v3 Announce Type: replace-cross Abstract: Evaluating large language models (LLMs) on their ability to generate high-quality, accurate, situationally aware answers to clinical questions requires going beyond conventional benchmarks to assess how these systems behave in complex, high-stakes clinical scenarios.

By Sandhanakrishnan Ravichandran, Shivesh Kumar, Rogerio Corga Da Silva, Miguel Romano, Reinhard Berkels, Michiel van der Heijden, Olivier Fail, Valentine Emmanuel Gnanapragasam
arXiv AI
Jul 29

PatientAgentBench: A Benchmark Framework for Evaluating Patient-Facing Health AI Agents

arXiv:2607. 25485v1 Announce Type: new Abstract: Health AI is evolving from answering questions to agentic systems that converse with patients, reason about health records, and act on their behalf.

By Korosh Vatanparvar, Ashutosh Joshi, Maria Xenochristou, Mohammad Abuzar Hashemi, Prasad Kasu, Deepak Bansal, Daniel Lopez-Martinez, Anchal Nema, Ramya Ganesan, Will Kimbrough, Alex Woody, Yadunandana Rao, Dilek Hakkani-Tur, Wilko Schulz-Mahlendorf
arXiv Computation and Language
Aug 27

Retrieval-Augmented Agentic Rubric Generation for Reliable Medical Response Evaluation

The paper introduces a retrieval‑augmented multi‑agent framework that automatically generates instance‑specific evaluation rubrics for medical language models. By retrieving authoritative medical evidence, decomposing it into atomic facts, and combining these with user interaction constraints, the system produces fine‑grained criteria that outperform GPT‑4o on HealthBench and LLMEval‑Med. The generated rubrics also guide response refinement, improving medical LLM output quality by 9.2%.

By Yinzhu Chen, Abdine Maiga, Hossein A. Rahmani, Emine Yilmaz