arXiv AI

Structured Evidence Routing for Incident Risk Prediction from Multimodal Longitudinal EHRs

The paper introduces structured evidence routing for incident risk prediction using multimodal longitudinal electronic health records (EHRs). It proposes a router‑predictor‑reviewer workflow that condenses full patient records into compact summaries and targeted evidence slices, enabling a predictor to generate evidence‑linked risk assessments that a reviewer can critique. Experiments on five one‑year incident diagnosis tasks show that the method matches the AUROC of established supervised EHRSHOT baselines and remains competitive on AUPRC, while providing a patient‑specific evidence trail.

arXiv Machine Learning
Aug 4

EHR2Path: Comprehensive Pathway-Level Modeling of Longitudinal Patient Trajectories from Multimodal Electronic Health Records

arXiv:2506. 04831v3 Announce Type: replace Abstract: Forecasting how a patient's condition is likely to evolve, including possible deterioration, recovery, treatment needs, and care transitions, could support more proactive and personalized care, but requires modeling heterogeneous and longitudinal electronic health record (EHR) data.

By Chantal Pellegrini, Ege \"Ozsoy, David Bani-Harouni, Matthias Keicher, Nassir Navab
arXiv Machine Learning
Jun 8

One Loss to Rule Them All: Marked Time-to-Event for Structured EHR Foundation Models

arXiv:2602. 00541v2 Announce Type: replace Abstract: Clinical events captured in Electronic Health Records (EHR) are irregularly sampled and may consist of a mixture of discrete events and numerical measurements, such as laboratory values or treatment dosages.

By Zilin Jing, Vincent Jeanselme, Yuta Kobayashi, Simon A. Lee, Chao Pang, Aparajita Kashyap, Yanwei Li, Xinzhuo Jiang, Shalmali Joshi
arXiv AI
3d ago

TRACER: A Multimodal Harness for Patient Care in Hospitals

TRACER is a training‑free multimodal harness that builds minute‑level action records from continuous video and merges them with clinical data into hourly reports, enabling an LLM agent to query and inspect both modalities. In evaluation, TRACER achieved up to 84.8% accuracy on action detection and 61.0% accuracy on clinician‑informed QA, outperforming the strongest baseline. Across 280 patients and ~60,000 camera‑hours, TRACER detected significantly less purposeful activity in patients with a positive delirium assessment compared to those without (p < 0.0001).

By Zane Durante, Paul Tang, Keshigeyan Chandrasegaran, Amit Kaushal, Shrinidhi Kowshika Lakshmikanth, Feolu Kolawole, Yu Jun Zheng, Yifan Geng, Shobhit Agarwal, Kevin Schulman, Juan Carlos Niebles, Ehsan Adeli, Arnold Milstein, Li Fei-Fei
arXiv AI
Jul 22

Trajectory-Aware Clinical Risk Prediction via Severity-Grounded Knowledge Graphs and Retrieval-Augmented Generation

arXiv:2607. 18270v1 Announce Type: new Abstract: While Electronic Health Records (EHRs) offer a wealth of clinical data, effectively augmenting a patient's records with heterogeneous external knowledge to predict the patient's clinical risk remains a significant challenge.

By Kyunghoon Jeon, Youmin Ko, Woohwan Jung, Hyunjoon Kim
arXiv AI
Jun 3

ChatHealthAI: Aligning Electronic Health Record Representations with Large Language Models for Grounded Clinical Reasoning

arXiv:2606. 02802v1 Announce Type: new Abstract: Large language models (LLMs) exhibit strong natural-language reasoning abilities for clinical decision support, but struggle to effectively model structured longitudinal electronic health records (EHRs).

By Bo-Hong Wang, Baicheng Peng, Ruilin Wang, Jun Bai, Ziyang Song, Yue Li
arXiv AI
Oct 5

RASPER: Reward-Aligned Summarization of Clinical Notes for EHR Outcome Prediction

RASPER is a reward‑aligned summarizer that tailors the extraction of information from unstructured discharge notes to improve downstream clinical predictions. It uses a tunable LLM summarizer trained with reinforcement learning, where the reward comes from the loss of a downstream predictor, and incorporates patient‑specific context via a longitudinal encoder that soft‑prompts the summarizer with structured codes. The approach consistently outperforms strong baselines on readmission prediction and medication recommendation tasks in the MIMIC‑III and MIMIC‑IV datasets.

By Arya Hadizadeh Moghaddam, Mohsen Nayebi Kerdabadi, Chen Chen, Dongjie Wang, Zijun Yao
arXiv Machine Learning
Aug 21

Explainable Transformer Models for Clinical Prediction Tasks on Structured Electronic Health Records

arXiv:2608. 20315v1 Announce Type: new Abstract: Predictive models over structured electronic health records (EHRs) remain central to machine learning for healthcare, but few have jointly emphasized quantitative laboratory information and interpretability with respect to input medical events.

By Jun Ni Du, Lukas Adamek, Maxim Kryukov, Flavio Dormont, Ziv Bar-Joseph, Sven Jager, Brandon Rufino
arXiv AI
Sep 18

CliniCIRCA: A Modular LLM Framework for Constructing Longitudinal Mental Health Patient Journeys from Raw EHR Narratives

CliniCIRCA is a modular large‑language‑model framework that reconstructs longitudinal mental‑health patient journeys from raw electronic health record narratives. It temporally classifies clinical events in unstructured discharge summaries without explicit timestamps, producing 15,891 tagged events from 52 summaries and correcting 629 errors to create verified gold‑standard timelines. The framework then generates temporally grounded summaries, compressing each source by 1.52×, and scales to produce 1,000 silver‑standard timelines for training, showing that instruction tuning improves event extraction, temporal tagging, and summarization across models.

By Aiwei Ivy Zhang, Nimra Ishfaq, Mohit Chandra, Santiago Alvarez Lesmes, Adam Coscia, Khatiya Chelidze Moon, Xiaohan Ding, Munmun De Choudhury
arXiv Machine Learning
Jul 20

LLM4EHR: Aligning Clinical Time Series with Medical Event Sequences via Large Language Models

arXiv:2607. 15447v1 Announce Type: new Abstract: Recent research in clinical machine learning, focusing on outcome predictions in intensive care unit (ICU), has shifted from bespoke supervised models to foundation models, utilising modern representation learning methods.

By Jingteng Li, Alexander Capstick, Louise Rigny, Iona Biggart, Neil J Sebire, Payam Barnaghi