arXiv:2608.22849v2 Announce Type: replace Abstract: Full-length RNAs, particularly messenger RNAs, often exceed the context lengths used to pretrain existing RNA foundation models, limiting complete-...
The paper introduces a multimodal framework that learns subcellularly resolved cell embeddings by integrating RNA expression profiles, protein sequence representations, and protein structural information using a cross‑attention architecture. This approach models interactions within distinct subcellular compartments, producing fine‑grained embeddings that capture both molecular expression patterns and functional protein properties. It is presented as the first method to jointly incorporate transcriptomic data, sequence, and structural knowledge for subcellularly resolved cell representation.
The paper introduces a multimodal framework that learns subcellularly resolved cell embeddings by integrating RNA expression profiles, protein sequence representations, and protein structural information. It uses a cross‑attention architecture to model interactions across distinct subcellular compartments, producing embeddings that capture both molecular expression patterns and functional protein properties. This approach is presented as the first to jointly incorporate transcriptomic data, protein sequences, and structural knowledge within a unified cross‑modal learning paradigm.
The paper introduces BCARP, a Biology‑Guided Context‑Aware Residual Propagation framework that predicts spatial gene expression from H&E‑stained histology images. Rather than directly decoding expression from visual features, BCARP treats histology embeddings as morphological priors and iteratively refines spot representations in a transcriptomics‑oriented latent space, integrating nuclei‑guided local context and prototype‑guided global propagation. Evaluations on three spatial transcriptomics datasets and ten HEST‑1k cohorts show that BCARP outperforms existing baselines in mean correlation‑based metrics, demonstrating the effectiveness of biology‑guided local‑global residual propagation for histology‑to‑transcriptomics prediction.
arXiv:2506. 11152v4 Announce Type: replace-cross Abstract: Single-cell transcriptomics and proteomics have become a great source for data-driven insights into biology, enabling the use of advanced deep learning methods to understand cellular heterogeneity and gene expression at the single-cell level.
arXiv:2608. 14710v1 Announce Type: cross Abstract: Predicting spatial gene expression from hematoxylin and eosin (H\&E)-stained images offers a cost-effective alternative to spatial transcriptomics (ST).
arXiv:2606. 07676v1 Announce Type: cross Abstract: Spatial transcriptomics (ST) is a powerful tool for exploring biological properties dependent on structure, proximity, and interaction in tissue.
The paper proposes a scalable framework that uses cell-level spatial transcriptomics (ST) as weak supervision for nuclei classification in histopathology images. By converting gene expression profiles into cell-type labels and leveraging nucleus masks from ST data, the method automatically generates image-label pairs without manual annotation. Evaluations on unseen tissues show that this approach achieves segmentation and classification performance comparable to conventional supervised methods while requiring fewer manually annotated datasets.
arXiv:2607. 14410v1 Announce Type: new Abstract: Spatially resolved omics studies increasingly combine transcriptomic and epigenomic assays, yet downstream analysis is often still performed using single-modality pipelines.
arXiv:2606. 13007v1 Announce Type: cross Abstract: Clustering is fundamental to scRNA-seq analysis, serving as a cornerstone for identifying cell populations and resolving tissue heterogeneity.
arXiv:2610.17699v1 Announce Type: new Abstract: Single-cell RNA sequencing (scRNA-seq) enables cell-level analysis of biological heterogeneity, but learning effective representations from high-dimens...
arXiv:2605.16392v2 Announce Type: replace-cross Abstract: Multiple instance learning (MIL) is the dominant framework for whole-slide image analysis in computational pathology, typically combining a f...