arXiv AI

Barycentric Fused Gromov-Wasserstein Balancing for Causal Inference under Multiple Treatments

arXiv Machine Learning
Sep 11

scDEFT: A deep learning framework for drug-effect prediction and counterfactual reasoning

scDEFT is a deep learning framework that treats a drug as a conditioning operator on single‑cell representations, enabling prediction of drug‑induced state changes and responder status. The model learns drug‑conditioned cell latents via feature‑wise linear modulation, aggregates them over transcriptional neighborhoods, and ranks latent dimensions to identify genes distinguishing responders from non‑responders. Applied to a harmonized inflammatory bowel disease atlas of 1.16 million cells, scDEFT achieves 45% of the baseline‑to‑reproducibility ceiling in state‑change prediction and stratifies responders before treatment with an AUROC of 0.70, outperforming standard predictors.

By Murthy Devarakonda
arXiv Machine Learning
Jun 26

Cross-Head Attention Uplift Network with Inverse Propensity Score under Unobserved Confounding

arXiv:2606. 27114v1 Announce Type: new Abstract: Uplift modeling, crucial for estimating individual treatment effects (ITE), faces dual challenges: flexibly leveraging inter-group similarity to enhance discriminative power and debiasing under unobserved confounding scenarios.

By Haoran Zhang, Chuanpu Li, Yuxin Fu, Bin Tong, Guan Wang, Bo Zheng, Feng Zhou