arXiv:2608.21864v1 Announce Type: cross
Abstract: The current progress of Clinical Vision Large Language Models (C-VLLMs) has substantially improved digital diagnostics, still these frameworks often...
By Md Asaduzzaman Jabin, Zihao Wu, Tianming Liu
The study introduces a scaffolding-oriented multi-agent Large Language Model (LLM) AI Standardized Patient (AI-SP) platform designed to train medical students in patient interviews. In a randomized controlled trial with 100 students, the multi-agent system—comprising a patient agent, a Socratic tutor agent, and a turn-level evaluator—did not improve diagnostic accuracy but significantly enhanced overall OSCE scores, especially in communication, empathy, and history-taking. The authors also release a richly annotated dataset to support further research in AI-supported clinical reasoning training.
By Luming Yang, Haoxian Liu, Siqing Li, Rong Jia, Yue Xiao, Guanhua Chen, Li Lu
arXiv:2609.39566v1 Announce Type: new
Abstract: Foundation models can serve as clinical agents through tool-use harnesses. However, conventional medical benchmarks assess reasoning over preselected e...
By Minye Shao, Chaohui Yu, Yixuan Wu, Fan Wang, Ling Shao, Yang Long
arXiv:2609.13543v1 Announce Type: new
Abstract: LLM agents are predominantly benchmarked on short, single-task trajectories, yet real deployments run for hours under contention, surfacing a different...
By Grace Chang Yuan, Xiaoman Zhang, Sung Eun Kim, Luyang Luo, Pranav Rajpurkar
arXiv:2606. 16149v3 Announce Type: replace Abstract: Rare disease diagnosis depends on expert reasoning that is scarce and difficult to transfer; off-the-shelf large language models (LLMs) rank the correct disease first in only 35.
By Minh-Ha Nguyen, Erica Gray, Bryce A. Schuler, Kevin W. Byram, Chih-Ting Yang, Fan Ma, Hua Xu, Wu-Chen Su, Chao Yan, Wei-Qi Wei, Adam Wright, Lisa Bastarache, Josh Peterson, Lingyao Li, Siyuan Ma, Undiagnosed Diseases Network, Rizwan Hamid, Thomas A. Cassini, Cathy Shyr
arXiv:2609.24480v1 Announce Type: cross
Abstract: Deploying Large Language Models (LLMs) in healthcare requires robust performance across two complementary dimensions - diagnostic reasoning: the conv...
By Kalash Shah, Kunal Singh, Snehan J, Shreyas Singh
arXiv:2606. 28692v1 Announce Type: new Abstract: Treatment reasoning underpins every therapeutic decision, integrating disease context, comorbidities, medications, contraindications, and evolving biomedical knowledge to select an appropriate therapy.
By Shanghua Gao, Ayush Noori, Richard Zhu, Curtis Ginder, Zhenglun Kong, Xiaorui Su, Justin Kauffman, Benjamin S. Glicksberg, Joshua Lampert, Ankit Sakhuja, Ashwin Sawant, ATHENA-R1 Evaluation Consortium, David A. Clifton, Noa Dagan, Ran Balicer, Marinka Zitnik
arXiv:2608. 16831v1 Announce Type: new Abstract: Generative pretraining established reusable task representations; later work on language-based task conditioning and in-context learning showed that a fixed model could adapt its behavior from instructions and demonstrations.
By Minh-Ha Nguyen, Cathy Shyr
arXiv:2607. 02983v1 Announce Type: new Abstract: Recent reasoning-centric Large Language Models (LLMs) have made significant strides, yet they predominantly operate on a passive-inference pattern that assumes complete information.
By Shengyi Hua, Kangzhe Hu, Conghui He, Xiaofan Zhang, Shaoting Zhang
The paper introduces MACD, a Multi-Agent Clinical Diagnosis framework that enables large language models to self‑learn clinical knowledge through a multi‑agent pipeline of summarization, refinement, and application. MACD is extended into a human‑AI collaborative workflow where multiple diagnostician agents consult iteratively, guided by a judge agent and human oversight. Evaluation on the MIMIC‑MACD cohort shows significant gains in diagnostic accuracy—an average 11.6 percentage‑point improvement over authoritative knowledge for open‑weight LLMs and an 18.3‑percentage‑point boost over physician‑only diagnosis in text‑only vignettes.
By Wenliang Li, Rui Yan, Xu Zhang, Li Chen, Hongji Zhu, Jing Zhao, Junjun Li, Mengru Li, Wei Cao, Zihang Jiang, Wei Wei, Kun Zhang, Shaohua Kevin Zhou
arXiv:2608. 03606v1 Announce Type: new Abstract: Clinical development is sequential decision-making under uncertainty, where a sponsor must plan a portfolio of experiments from heterogeneous evidence.
By William Bolton, Philip Torr
arXiv:2606. 28900v1 Announce Type: new Abstract: Doctor agents are moving beyond single-turn answer generation toward evolving clinical decision systems.
By Hui Zhang