arXiv:2606. 16149v3 Announce Type: replace Abstract: Rare disease diagnosis depends on expert reasoning that is scarce and difficult to transfer; off-the-shelf large language models (LLMs) rank the correct disease first in only 35.
By Minh-Ha Nguyen, Erica Gray, Bryce A. Schuler, Kevin W. Byram, Chih-Ting Yang, Fan Ma, Hua Xu, Wu-Chen Su, Chao Yan, Wei-Qi Wei, Adam Wright, Lisa Bastarache, Josh Peterson, Lingyao Li, Siyuan Ma, Undiagnosed Diseases Network, Rizwan Hamid, Thomas A. Cassini, Cathy Shyr
arXiv:2606. 28692v1 Announce Type: new Abstract: Treatment reasoning underpins every therapeutic decision, integrating disease context, comorbidities, medications, contraindications, and evolving biomedical knowledge to select an appropriate therapy.
By Shanghua Gao, Ayush Noori, Richard Zhu, Curtis Ginder, Zhenglun Kong, Xiaorui Su, Justin Kauffman, Benjamin S. Glicksberg, Joshua Lampert, Ankit Sakhuja, Ashwin Sawant, ATHENA-R1 Evaluation Consortium, David A. Clifton, Noa Dagan, Ran Balicer, Marinka Zitnik
arXiv:2608. 16831v1 Announce Type: new Abstract: Generative pretraining established reusable task representations; later work on language-based task conditioning and in-context learning showed that a fixed model could adapt its behavior from instructions and demonstrations.
By Minh-Ha Nguyen, Cathy Shyr
arXiv:2607. 02983v1 Announce Type: new Abstract: Recent reasoning-centric Large Language Models (LLMs) have made significant strides, yet they predominantly operate on a passive-inference pattern that assumes complete information.
By Shengyi Hua, Kangzhe Hu, Conghui He, Xiaofan Zhang, Shaoting Zhang
arXiv:2608. 03606v1 Announce Type: new Abstract: Clinical development is sequential decision-making under uncertainty, where a sponsor must plan a portfolio of experiments from heterogeneous evidence.
By William Bolton, Philip Torr
arXiv:2606. 28900v1 Announce Type: new Abstract: Doctor agents are moving beyond single-turn answer generation toward evolving clinical decision systems.
By Hui Zhang
arXiv:2601. 16529v4 Announce Type: replace Abstract: Large language models (LLMs) deployed in clinical decision support may acquiesce to patient requests for care that conflicts with evidence-based guidelines.
By Dongshen Peng, Yi Wang, Austin Schoeffler, Sun-ha Hong, Brian Suffoletto, David Kim, Carl Preiksaitis, Christian Rose
arXiv:2608. 16211v1 Announce Type: new Abstract: Long-horizon agents are beginning to automate complete workflows that produce code, reports, and research artifacts.
By Junqi Liu, Yufan He, Yexiao He, Pengfei Guo, Dong Yang, Andriy Myronenko, Can Zhao, Hanrong Ye, Tianhao Qi, Yuyin Zhou, Daguang Xu, Yucheng Tang
arXiv:2603. 25821v3 Announce Type: replace-cross Abstract: We present Doctorina MedBench, an evaluation framework for agent-based medical AI based on the simulation of physician-patient interactions.
By Anna Kozlova, Stanislau Salavei, Pavel Satalkin, Hanna Plotnitskaya, Sergey Parfenyuk, Andy Nkansah
arXiv:2605. 29668v2 Announce Type: replace Abstract: LLM agents acting in structured environments fail in operational rather than conversational ways, and reliability depends on procedural knowledge of the environment.
By Johannes Moll, Jean-Philippe Corbeil, Jiazhen Pan, Martin Hadamitzky, Daniel Rueckert, Lisa Adams, Keno Bressem
arXiv:2607. 25485v1 Announce Type: new Abstract: Health AI is evolving from answering questions to agentic systems that converse with patients, reason about health records, and act on their behalf.
By Korosh Vatanparvar, Ashutosh Joshi, Maria Xenochristou, Mohammad Abuzar Hashemi, Prasad Kasu, Deepak Bansal, Daniel Lopez-Martinez, Anchal Nema, Ramya Ganesan, Will Kimbrough, Alex Woody, Yadunandana Rao, Dilek Hakkani-Tur, Wilko Schulz-Mahlendorf
arXiv:2603. 25821v2 Announce Type: replace-cross Abstract: We present Doctorina MedBench, a comprehensive evaluation framework for agent-based medical AI based on the simulation of realistic physician-patient interactions.
By Anna Kozlova, Stanislau Salavei, Pavel Satalkin, Hanna Plotnitskaya, Sergey Parfenyuk