The study explores acoustic biomarkers derived from spontaneous speech to differentiate Alzheimer's disease patients from healthy controls. Using a structured picture‑description task, low‑level prosodic, spectral, and temporal features were extracted and fed into various machine learning classifiers. The best models achieved clinically meaningful separation between diagnostic groups, indicating that non‑invasive audio screening could aid early detection of dementia.
arXiv:2607. 10168v1 Announce Type: cross Abstract: It is still hard to find Alzheimer's disease (AD) early, especially when neuroimaging is expensive or tools that depend on language are not available.
arXiv:2502. 03484v3 Announce Type: replace-cross Abstract: Dementia encompasses a group of syndromes that impair cognitive functions such as memory, reasoning, and the ability to perform daily activities.
The study investigates whether acoustic factors encoded in pretrained self‑supervised learning (SSL) models can systematically influence predictions in speech‑based Alzheimer's disease (AD) assessment. Using the ADReSSo dataset and three large SSL backbones, the authors applied controlled noise and reverberation interventions to various audio segments and combined layer‑wise decoding, input‑ and representation‑space interventions, and geometric alignment analysis. The results demonstrate that such acoustic interventions alter AD predictions across all models, with noise producing the strongest effect, and that these effects are structured relative to the classifier’s decision direction and reproducible on a held‑out test set.
arXiv:2608. 07378v1 Announce Type: cross Abstract: Early diagnosis of Alzheimer's disease (AD) is critical for enabling timely interventions that may slow disease progression and improve patient outcomes.
The study examines how speech preprocessing—such as enhancement, sample selection, and demographic balancing—affects Alzheimer’s disease detection models that use the Pitt Corpus. Experiments reveal that while speech‑enhanced datasets boost in‑domain accuracy, they diminish cross‑dataset robustness and introduce class imbalance and prediction shifts, even when training and testing enhancements are matched. Large audio‑language models show similar sensitivity, indicating that cleaner speech does not guarantee better real‑world performance.
arXiv:2606. 30675v1 Announce Type: cross Abstract: Early detection of dementia through speech analysis offers a non-invasive screening alternative, but capturing both acoustic and linguistic biomarkers remains challenging.
arXiv:2607. 21496v1 Announce Type: cross Abstract: Cognitive impairment (CI) is a growing public health concern.
The paper examines why speech‑based screening for Alzheimer’s disease fails to generalize across different languages, tasks, and recording protocols. Using a leave‑one‑corpus‑out evaluation on four datasets, it finds that 59 of 70 interpretable speech features show conflicting patterns between healthy controls and cognitive risk groups, with pause, silence, and speech rate being highly protocol‑sensitive. The authors propose a fusion method that combines XLM‑R text baseline scores with evidence anchors, improving mean speaker AUC to 0.785 and worst‑case AUC to 0.615, and emphasize the importance of auditing feature transferability and reporting worst‑case domain robustness.
Speech-based Alzheimer's disease (AD) detection increasingly relies on speech-enhanced and curated versions of the Pitt Corpus, where speech enhancement, sample selection, and demographic balancing ar...
arXiv:2607. 23977v1 Announce Type: cross Abstract: Acoustic biomarkers show promise for detecting Alzheimer's Disease (AD), yet whether the cues driving diagnostic AI align with those salient to human listeners is underexplored across languages and genders, where pathological markers and perceptual strategies differ.
The paper introduces LLM-Anchored Paralinguistic Enrichment (LAPE), a method that enhances language model representations with speech-based paralinguistic cues such as pauses and word elongations. LAPE incorporates three innovations: prosodic event textualization, lexico-prosodic unitization and chunking, and text-anchored paralinguistic fusion using NormGate. Evaluations on the ADReSS and ADReSSo datasets show that LAPE achieves state‑of‑the‑art performance in detecting Alzheimer’s disease from speech.
The study presents a Korean elderly speech corpus of 89 MCI speakers collected over three years, accompanied by concurrent depression (SGDS) and cognitive (MMSE) assessments. Analysis using linear mixed-effects models and partial correlations revealed that only formant features are associated with depression after controlling for cognitive function, while F0 features show no signal. A subset of formant features (F1+F2) achieved a UAR of 0.760 with just 12 features, outperforming both the full eGeMAPS baseline and self-supervised representations.