The paper introduces MIMIC-DOS, a dataset derived from MIMIC-IV that focuses on ICU cases where patient symptoms and medical signs are discordant. It presents CARE, a privacy‑compliant multi‑stage agentic reasoning framework that uses a proprietary LLM to generate structured categories and transitions, while a local LLM performs evidence acquisition and decision‑making. In retrospective evaluations on MIMIC‑DOS, CARE outperforms other LLMs and agentic workflows, demonstrating stronger handling of conflicting clinical evidence while preserving patient privacy.
By Haochen Liu, Weien Li, Rui Song, Zeyu Li, Chun Jason Xue, Xiao-Yang Liu, Sam Nallaperuma-Herzberg, Xue Liu, Ye Yuan
arXiv:2608.21948v1 Announce Type: new
Abstract: Complex clinical reasoning requires models to update diagnostic hypotheses as new evidence emerges and to coordinate different medical specialities und...
By Sike Xiang, Shuang Chen, Qian sun, Jia Cheng, Yusi Wei, Amir Atapour-Abarghouei
arXiv:2608.27856v1 Announce Type: new
Abstract: Recent advances in large language models are enabling autonomous clinical agents to perform increasingly complex electronic health record (EHR) modelin...
By Jun Bai, Ruilin Wang, Yue Li
arXiv:2409. 15723v3 Announce Type: replace Abstract: Large Language Models have achieved impressive performance across diverse applications, yet their training typically depends on centralized data collection, raising serious privacy and governance concerns.
By Yuhang Yao, Jianyi Zhang, Junda Wu, Chengkai Huang, Yu Xia, Tong Yu, Ruiyi Zhang, Sungchul Kim, Ryan Rossi, Ang Li, Lina Yao, Julian McAuley, Yiran Chen, Carlee Joe-Wong
arXiv:2606. 26797v1 Announce Type: new Abstract: Supervised fine-tuning (SFT) on a small, high-quality set of long reasoning traces is an effective approach for eliciting strong reasoning capabilities in Large Language Models (LLMs).
By Hongyi Henry Jin, Wenhan Yang, Meysam Ghaffari, Carlos Morato, Baharan Mirzasoleiman
arXiv:2610.08093v1 Announce Type: cross
Abstract: Developing reliable models for clinical tasks, such as Medical Question Answering (QA), is severely constrained by the limited availability of high-q...
By Chuan Li, Chengyu Wang, Cen Chen, Ye Lyu, Mingyuan Fan, Ming Gao
The paper reviews how Large Language Models (LLMs) are being adapted for medical reasoning, moving beyond single-step answers to systems that can systematically, transparently, and verifiably reason. It introduces a taxonomy of enhancement techniques, split into training-time methods such as supervised fine‑tuning and reinforcement learning, and test-time methods like prompt engineering and multi‑agent systems. The review examines their application across text, image, and code modalities in key clinical areas—diagnosis, education, and treatment planning—and tracks the shift in evaluation benchmarks from simple accuracy to more nuanced assessments of reasoning quality and visual interpretability.
By Zizhan Ma, Wenxuan Wang, Meidan Ding, Shiyi Zheng, Shengyuan Liu, Jie Liu, Jiaming Ji, Linlin Shen, Yixuan Yuan, Wenting Chen
Supervised fine-tuning (SFT) on a small, high-quality set of long reasoning traces is an effective approach for eliciting strong reasoning capabilities in Large Language Models (LLMs). However, existing methods for curating high-quality SFT data rely heavily on strong reasoning models to filter examples based on diversity and difficulty, making the curation process costly while often yielding suboptimal data quality.
arXiv:2310. 16152v5 Announce Type: replace-cross Abstract: Federated learning (FL) has become a key component in various language modeling applications such as machine translation, next-word prediction, and medical record analysis.
By Md Rafi Ur Rashid, Vishnu Asutosh Dasu, Kang Gu, Najrin Sultana, Shagufta Mehnaz
arXiv:2607. 19678v1 Announce Type: cross Abstract: AI-generated answers in high-stakes domains are often fluent but difficult to verify, especially when they contain multi-step reasoning rather than a single final answer.
By Guneet Singh Kohli, Yuxiang Zhou, Michael Sejr Schlichtkrull, Gregory E Dean, Maria Liakata
arXiv:2609.15871v1 Announce Type: cross
Abstract: Rising societal and lifestyle complexity has been linked to a growing prevalence of mental distress worldwide. Educational institutions, workplaces,...
By Md Khalid Syfullah, Alvi Ataur Khalil
arXiv:2608.22622v1 Announce Type: cross
Abstract: Clinical decision-making relies on identifying relevant patient information to guide diagnosis and treatment, a challenge that is especially difficul...
By Miguel Contreras, Scott Siegel, Subhash Nerella, Jessica Sena, Jiaqing Zhang, Heng Sun, Hruday Tej Akkaladevi, Peiyu Lu, Jordan Rosen, Sumit Kapoor, Sasank Desaraju, Grace R. Thompson, Jacob Purcell, Michael Petrauskis, Philip KW. Hong, Meghan Brennan, Sarah Chrabaszcz, Tierra Smith, Ronnie Ren, Michel S. Kabbash, Ceyhun Haziroglu, Rushi Patel, Gabriel Gomez, Charlotte Chaiklin, Randy Leung, Kenneth N. John, Whitman Wiggins, Philip Kayser, Vincent Bird, Maria Bruzzone, Tyler J. Loftus, Azra Bihorac, Parisa Rashidi