Accelerating Protein Language Model ProtST on Intel Gaudi 2
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ProtLingo: Efficient Protein Language Modeling via Conditional Memory and Expert Routing
ProtLingo is a protein language modeling framework that enhances a pretrained single‑sequence Transformer backbone with conditional local memory and sparse expert routing. It maps residue representations into discrete codes, composes local windows into latent N‑gram addresses, and retrieves reusable residual signals for recurring sequence contexts. The model also converts selected feed‑forward blocks into sparse Mixture‑of‑Experts layers, allowing residue‑dependent computation while activating only a subset of parameters, achieving competitive performance on protein fitness prediction, FLIP benchmarks, and supervised contact prediction with a 150M‑parameter backbone.
LEMON-ZEST: Evolution-Informed Tokenization for Efficient Protein Language Modeling
arXiv:2609.37675v1 Announce Type: new Abstract: Protein Language Models (PLMs) have made remarkable progress following scaling laws established in natural language processing across sequence- and str...
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Analysis of Quantized and Efficiently Adapted Protein Language Models
The study evaluates 4‑bit quantization and low‑rank adapter fine‑tuning (QLoRA) on several large protein language models, finding that many model‑task pairs retain over 90% of full fine‑tuning performance while achieving up to 90% GPU memory savings. QLoRA preserves early‑layer representations and induces task‑specific changes in later layers, closely resembling full fine‑tuning with smaller representational shifts. For generative models, 4‑bit quantization largely maintains structural and sequence‑level properties, though token‑level analysis reveals model‑dependent changes in autoregressive output distributions.
OpenLanguageModel: Readable and Composable Small-Language-Model Pretraining for Education and Research
arXiv:2607. 16669v1 Announce Type: cross Abstract: OpenLanguageModel (OLM) is an open-source PyTorch library for building and pretraining small language models while keeping their machinery visible.
ProteinJEPA: Latent prediction improves protein language model pretraining
ProteinJEPA introduces a joint‑embedding predictive architecture that supplements masked language modeling (MLM) with a cosine loss to predict latent representations of a teacher model. On 19 protein tasks, MLM+JEPA outperforms compute‑matched and step‑matched MLM‑only training across 78 and 76 of 114 comparisons, achieving notable gains on structure‑ and homology‑sensitive tasks such as SCOPe‑40 retrieval and remote homology. Ablation studies show the cosine loss is superior to mean squared error and that latent prediction complements rather than replaces MLM.
AutoProteinEngine: A Large Language Model Driven Agent Framework for Multimodal AutoML in Protein Engineering
arXiv:2411. 04440v1 Announce Type: cross Abstract: Protein engineering is important for biomedical applications, but conventional approaches are often inefficient and resource-intensive.
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PDFBench: A Benchmark for De novo Protein Design from Function
arXiv:2505. 20346v3 Announce Type: replace-cross Abstract: Function-guided protein design is a crucial task with significant applications in drug discovery and enzyme engineering.