arXiv AI

ProteinJEPA: Latent prediction improves protein language model pretraining

ProteinJEPA introduces a joint‑embedding predictive architecture that supplements masked language modeling (MLM) with a cosine loss to predict latent representations of a teacher model. On 19 protein tasks, MLM+JEPA outperforms compute‑matched and step‑matched MLM‑only training across 78 and 76 of 114 comparisons, achieving notable gains on structure‑ and homology‑sensitive tasks such as SCOPe‑40 retrieval and remote homology. Ablation studies show the cosine loss is superior to mean squared error and that latent prediction complements rather than replaces MLM.

arXiv Machine Learning
Sep 11

When do cheap embeddings beat protein language models? A theoretically-grounded hashing sketch for biological sequence classification

The paper introduces Murmur2Vec, a lightweight, alignment‑free embedding that uses k‑mer counts hashed with MurmurHash to create a compact representation for biological sequences. It provides a full theoretical analysis, including bias/variance formulas, a Johnson–Lindenstrauss‑style concentration bound, and an excess‑risk bound that clarifies the trade‑off between hash‑table size and classifier performance. Empirically, Murmur2Vec matches or surpasses a fine‑tuned 650M‑parameter ESM‑2 protein language model across several classification tasks, including SARS‑CoV‑2 spike lineage and HIV‑1 Env subtype identification.

By Sarwan Ali, Taslim Murad, Imdadullah Khan, Safi Faizullah
arXiv Computation and Language
Sep 11

NCP-ArchPreview Technical Report: Moving towards Latent Space Language Models through Next Concept Prediction

NCP-ArchPreview is a latent‑space language model that extends standard next‑token prediction (NTP) with a Next Concept Prediction (NCP) objective, allowing the model to predict discrete concepts spanning multiple tokens. The architecture builds a product‑quantized concept vocabulary from hidden states, uses a dedicated Concept Module to forecast future concepts, and feeds these predictions back to guide token‑level generation, all trained jointly end‑to‑end. Trained on 5.73 T tokens with 8.9 B parameters, it achieves the final pretraining loss of OLMo‑3‑7B using only 51.3 % of the tokens, outperforms OLMo‑3‑7B on downstream tasks (including a 5.99‑point GSM8K gain), and demonstrates that the learned latent space enables lightweight domain adaptation and improved drafting performance.

By NCP Team, Jiaqi Cao, Chiyu Chen, Shuang Cheng, Xu Cheng, Beiya Dai, Yufan Feng, Kewen Ge, Ruijun Ge, Jiayi Huang, Yang Jiao, Dahua Lin, Zhouhan Lin, Yifan Liu, Yuliang Liu, Biqing Qi, Mowen Ruan, Junzhe Shen, Yunchong Song, Hao Sun, Zhongbo Tian, Yixuan Wang, Rubin Wei, Jiaxin Xiong, Kangyu Yang, Qian Yao, Qi Zhang, Bowen Zhou
arXiv Computation and Language
Sep 10

Osprey: Target-agnostic Pre-training Makes Stronger Drafters in Speculative Decoding

Osprey is a target‑agnostic pre‑training method that bootstraps draft models for speculative decoding from existing small language models. By pruning to a shallow backbone, restoring language‑modeling capability with next‑token pretraining, and adapting via vocabulary alignment and distillation, Osprey reduces per‑target work to a lightweight adaptation step. Experiments show that a single Osprey backbone improves mean acceptance length by up to 22.7% and increases tokens per second by 17.5% across several large target models, especially on out‑of‑domain and multilingual data.

By Fengxiang Bie, Yuqing Jian, Yifan Yu, Zhongzhu Zhou, Zelei Shao, Ben Athiwaratkun, Shuaiwen Leon Song, Chenfeng Xu, Xiaoxia Wu, Tianyi Zhang
arXiv AI
Jun 18

Clin-JEPA: A Multi-Phase Co-Training Framework for Joint-Embedding Predictive Pretraining on EHR Patient Trajectories

arXiv:2605. 10840v3 Announce Type: replace-cross Abstract: We present Clin-JEPA, a multi-phase co-training framework for joint-embedding predictive (JEPA) pretraining on EHR patient trajectories.

By Yixuan Yang, Mehak Arora, Ryan Zhang, Baraa Abed, Junseob Kim, Tilendra Choudhary, Md Hassanuzzaman, Kevin Zhu, Ayman Ali, Chengkun Yang, Alasdair Edward Gent, Victor Moas, Rishikesan Kamaleswaran
arXiv Machine Learning
Sep 17

Subspace-Decomposed JEPAs: Disentangling Progression and Content in Latent World Models

Subspace-Decomposed JEPAs (SD-JEPA) split the latent space of Joint-Embedding Predictive Architectures into two orthogonal subspaces: a low-dimensional progression subspace trained with a cosine-margin triplet loss and a high-dimensional content subspace regularised by SIGReg. The authors prove that the anti-collapse forces act on disjoint coordinates, allowing additive composition rather than competition. SD-JEPA outperforms the LeWM baseline on most control benchmarks and the strongest non-LeWM JEPA baseline on Push‑T, with a subspace-ablation confirming the split as essential. The 1‑D angular progression coordinate serves as a scene-aware compass, advancing with task progress, regressing on backtracking, and relocalising under perturbations to separate surprise from meaning.

By Lucas Thil, Jesse Read, Rim Kaddah, Guillaume Doquet