arXiv AI

A Language-Guided Multimodal Foundation Model for Zero-Shot and Multi-Task Brain Signal Analysis

arXiv AI
6d ago

Combining General and Domain-Specific Pretext Tasks for Brain MR Image Segmentation

The paper investigates combining a domain‑specific self‑supervised task—voxel‑level brain age prediction—with a general task—image inpainting—to pretrain models for brain MRI segmentation. A multitask pretraining framework jointly optimizes both objectives, yielding representations that outperform single‑task pretraining and training from scratch on three segmentation benchmarks (multiple sclerosis lesions, ischemic stroke lesions, and cortical structures). The study demonstrates that integrating domain‑specific and general self‑supervised tasks benefits the development of generalizable neuroimaging foundation models.

By Tasneem Nasser, Susanne Schmid, Roberto Souza, Naser El-Sheimy
arXiv Computer Vision
Sep 14

Learning Sparse Latent Predictive Foundation Model for Multimodal Neuroimaging

The paper introduces Neuro‑JEPA, a sparse multimodal foundation model that learns unified representations of brain MRI across T1w, T2w, and FLAIR sequences using a latent predictive objective and a Mixture‑of‑Experts architecture. It was pretrained on over 1.5 million scans from 428,647 studies and systematically evaluates architectural, masking, objective, and sparsity choices for robust multimodal representation learning. Across 47 tasks from three health systems and 12 public datasets, Neuro‑JEPA consistently outperforms a simple CNN baseline, demonstrating its effectiveness for both clinical and research applications.

By Haoxu Huang, Long Chen, Jingyun Chen, Jinu Hyun, James Ryan Loftus, Kara Melmed, Daniel Orringer, Jennifer Frontera, Seena Dehkharghani, Arjun Masurkar, Narges Razavian
arXiv Machine Learning
Sep 7

Brain4FMs: A Benchmark of Foundation Models for Electrical Brain Signal

Brain4FMs is a unified benchmark for evaluating brain foundation models (BFMs) on both scalp EEG and intracranial EEG (iEEG). It incorporates 17 representative models and 21 public datasets spanning clinical diagnosis, sleep staging, communication, and affective computing, and offers dataset-aware preprocessing, cross‑subject evaluation, and standardized downstream workflows. The benchmark highlights that no single BFM consistently outperforms others across all tasks, modalities, and adaptation protocols, prompting further exploratory analyses of model‑specific spatial, spectral, and discrete representations.

By Fanqi Shen, Enhong Yang, Jiahe Li, Junru Hong, Xiaoran Pan, Zhizhang Yuan, Meng Li, Yang Yang
arXiv Machine Learning
Jul 17

Multimodal Semantic-Aware Contrastive Learning For False Negative Mitigation in 3D Medical Imaging

arXiv:2607. 14995v1 Announce Type: new Abstract: Multimodal Contrastive Learning (CL) has shown significant performance in aligning representations across various data modalities and improving downstream tasks, especially in healthcare.

By Sara Ketabi, Matthias W. Wagner, Cynthia Hawkins, Uri Tabori, Birgit Betina Ertl-Wagner, Farzad Khalvati
arXiv AI
Jul 14

PivotMerge: Bridging Heterogeneous Multimodal Pre-training via Post-Alignment Model Merging

arXiv:2604. 22823v2 Announce Type: replace-cross Abstract: Multimodal Large Language Models (MLLMs) rely on multimodal pre-training over diverse data sources, where different datasets often induce complementary cross-modal alignment capabilities.

By Zibo Shao, Baochen Xiong, Xiaoshan Yang, Yaguang Song, Qimeng Zhang, Haifeng Chen, Changsheng Xu
arXiv AI
Jun 2

UF-AMA: A unified framework for cross-domain emotion recognition via adaptive multimodal alignment

arXiv:2606. 00170v1 Announce Type: cross Abstract: In recent years, emotion recognition based on physiological signals such as electroencephalogram (EEG) has gained considerable attention, as internal physiological data offer greater objectivity and reliability compared to external behavioral data like facial expressions.

By Zheng Wang, Shuo Wang, Junhong Wang
arXiv Machine Learning
Sep 21

BrainWideBench: Benchmarking large-scale pretraining and across-animal transfer in multi-region neural recordings

BrainWideBench is a benchmark that evaluates across‑animal transfer on multi‑region neural recordings from 139 mice, covering 276 brain regions. It comprises three task suites—behavior decoding, neural activity prediction, and anatomical organization recovery—to test whether learned representations support diverse downstream objectives. The benchmark shows that while pretraining improves performance over single‑session baselines, current methods vary in transfer ability and none perform uniformly well across all suites, highlighting the challenge of developing general‑purpose neural representations.

By Alexandre Andre, Shivashriganesh P. Mahato, Vinam Arora, Keshav Balaji, Divyansha Lachi, Nanda H. Krishna, Jingyun Xiao, Yizi Zhang, Ximeng Mao, Wenrui Ma, Han Yu, International Brain Laboratory, Daniel Birman, Niccol\`o Bonacchi, Gaelle A. Chapuis, Joana A. Catarino, Felicia Davatolhagh, Mayo Faulkner, Laura Freitas-Silva, Fei Hu, Julia M. Huntenburg, Anup Khanal, In\^es Laranjeira, Petrina Lau, Guido T. Meijer, Nathaniel J. Miska, Jean-Paul Noel, Alejandro Pan-Vazquez, Georg Raiser, Cyrille Rossant, Karolina Z. Socha, Anne E. Urai, Miles J. Wells, Steven J. West, Olivier Winter, Blake Richards, Guillaume Lajoie, Cole Hurwitz, Mehdi Azabou, Matthew R. Whiteway, Liam Paninski, Eva L. Dyer
arXiv Machine Learning
Aug 4

EEG-FM-Compass: Progress, Benchmarking, and Future Directions for EEG Foundation Models

arXiv:2601. 17883v3 Announce Type: replace Abstract: Electroencephalography (EEG) foundation models (FMs) have recently emerged as a promising paradigm for brain-computer interfaces, aiming to learn transferable neural representations from large-scale heterogeneous recordings.

By Dingkun Liu, Yuheng Chen, Zhu Chen, Zhenyao Cui, Yaozhi Wen, Jiayu An, Jingwei Luo, Dongrui Wu
arXiv Machine Learning
Jun 10

When to Align, When to Predict: A Phase Diagram for Multimodal Learning

arXiv:2606. 11190v1 Announce Type: new Abstract: Cross-modal alignment (CA) and cross-modal prediction (CP) are the dominant paradigms for multimodal representation learning, yet there is no systematic understanding of when each succeeds, when each fails, and when cross-modal training helps at all -- a gap that leaves practitioners, especially in scientific domains like biomedicine or astrophysics, with heterogeneous instruments and multiple levels of organization and measurement, unable to diagnose why standard methods underperform the best single modality.

By Ilay Kamai, Hugues Van Assel, Aviv Regev, Hagai B. Perets, Randall Balestriero