arXiv:2602.20773v2 Announce Type: replace
Abstract: Purpose: Developing generalizable medical image segmentation models is challenging because imaging data are distributed across institutions and dif...
By Sachin Dudda Nagaraju, Ashkan Moradi, Bendik Skarre Abrahamsen, Mattijs Elschot
nnFoundation introduces complementary convolutional and transformer-based 3D foundation models for radiology, trained on 2.1 million CT, MRI, and PET volumes from 125 datasets. The models are evaluated on 108 tasks—including segmentation, detection, classification, report generation, and image retrieval—under domain shift, low-data, and low-compute scenarios, consistently outperforming prior 3D foundation models and training from scratch. Performance varies by task type, with convolutional models excelling at spatially localized tasks and transformer models at global semantic reasoning, and dynamic alignment with dataset characteristics further enhances transferability.
By Constantin Ulrich Harsy, Tassilo Wald, Karol Gotkowski, Yannick Kirchhoff, Marcel Knopp, Maximilian Rokuss, Elisa Stegmeier, Philipp Schader, Dasha Trofimova, Raphael Stock, Kim-Celine Kahl, Stephen Schaumann, Selen Erkan, David Zimmerer, Stefan Denner, Moritz Langenberg, Sebastian Ziegler, Katharina Eckstein, Maximilian Fischer, Jonathan Suprijadi, B\'alint Kov\'acs, Benjamin Hamm, Anand Deshpande, Dimitrios Bounias, Nico Disch, Shuhan Xiao, Jessica K\"achele, Jan Sellner, Rajesh Baidya, Jeremias Traub, Lars Kr\"amer, Maximilian Zenk, Tim R\"adsch, Stefan Dvoretskii, Robin Peretzke, Jonathan Deissler, Alexandra Ertl, Partha Ghosh, Kris Dreher, Stefan Dinkelacker, Annika Reinke, Evangelia Christodoulou, Numan Saeed, Yoland Savriama, Santiago Estrada, David K\"ugler, Laura Alexandra Daza Barragan, Cristina Isabel Gonzalez Osorio, Jan Peeken, Michael Baumgartner, Marvin Teichmann, Guillaume Chabin, Matthias Kirchler, Valentin Koch, for the ALFA study, Markus Hohenhaus, Dimitri Koslov, Nina Decker, Mohammad Yaqub, Arnd Heuser, Martin Reuter, Julia A. Schnabel, Tobias Heimann, Florin Ghesu, Paul Brachmann, Claus P. Heu{\ss}el, Alexander Radbruch, Gianluca Brugnara, Aditya Rastogi, Martha Foltyn-Dumitru, Heinz-Peter Schlemmer, Ignaz Reicht, Julius C. Holzschuh, Michael Bach, Bram Stieltjes, Kai Schlamp, Lena Maier-Hein, Marco Nolden, Ralf Floca, Paul F. J\"ager, Philipp Vollmuth, Fabian Isensee, Klaus H. Maier-Hein
The paper introduces Segment Anything Small (SAS), a data‑augmentation method that improves deep‑learning segmentation of small anatomical structures in ultrasound images. SAS uses two transformations: resizing and embedding organ thumbnails into a black background to vary organ scale, and adding noise to regions of interest to mimic tissue texture variability. Experiments on one internal and five external datasets show Dice score gains up to 0.35, with an average improvement of 0.16, and demonstrate that SAS enhances model robustness and generalizability without adding hallucinations or artifacts.
By Danielle L. Ferreira, Ahana Gangopadhyay, Hsi-Ming Chang, Ravi Soni, Gopal Avinash
The paper presents a modality‑routed 3D cardiac segmentation pipeline that combines TotalSegmentator‑initialized nnU‑Netv2 models with site‑characterized, label‑preserving appearance augmentation. By analyzing measurable image properties across sites, the authors design a bias‑field plus Bezier augmentation strategy that smooths spatial intensity perturbations and remaps intensities nonlinearly, followed by class‑wise largest‑connected‑component cleanup. On held‑out validation splits, this approach raises CT mean Dice from 0.8350 to 0.9135 and MRI mean Dice from 0.7695 to 0.7830 while reducing HD95, demonstrating improved cross‑site robustness in limited‑data whole‑heart segmentation.
By Tanish Mudaliar, Justin Li, Daniel Lin, Julianna Vo, Kaitao Liao, Xin Wang, Shu Hu
The paper introduces the Real‑Calibrated Synthetic‑First Data Engine, a modular pipeline that integrates controllable diffusion‑based synthetic image generation with multi‑stage curation, filtering, and optional uncertainty‑driven selection and human verification. Designed as a CLI‑based framework, it allows independent configuration of generation, filtering, selection, and validation modules to enhance reproducibility and flexibility in real‑world data workflows. Empirical tests on human pose estimation demonstrate that synthetic data can boost a real‑data baseline when used as low‑cost augmentation, though synthetic‑only training still lags behind real‑only performance, underscoring the importance of data‑centric orchestration in low‑data regimes.
By Yukang Shen, Zhiguo Liu, Yingshu Li, Yan Huang
Whole-heart segmentation from CT and MRI is essential for quantitative cardiac image analysis, but remains challenging under multi-center and multi-modality distribution shift. In the CARE whole-heart...
arXiv:2608.24364v1 Announce Type: new
Abstract: Self-supervised pretraining enables transferable representations for medical imaging, yet most CT encoders remain biased toward coarse semantic underst...
By Sebasti\'an Gonz\'alez, Karen Sanchez, Jos\'e M. Saavedra, Marcelo Pizarro, Bernard Ghanem
arXiv:2609.21698v1 Announce Type: new
Abstract: Deep learning segmentation of renal tumors requires large annotated datasets, yet clinical deployments typically offer only a handful of tumor-positive...
By Ekaterina Sedykh, Salme Ussanov, Dmytro Fedorenko, Dmytro Fishman
arXiv:2608.22619v1 Announce Type: cross
Abstract: Generative segmentation provides an alternative to direct pixel-wise prediction by operating on learned latent representations, but effective image-t...
By Md Maklachur Rahman, Md Hasan Al Banna, Saraf Anjum, Mahmudul Hasan, Tracy Hammond
Congenital heart disease (CHD) diagnosis and surgical planning often require patient-specific 3D anatomical models, but manual segmentation is labor-intensive, particularly in complex anatomies. Altho...
The paper introduces SSS, a semi‑supervised framework that builds on the Vision Foundation Model SAM‑2 to improve medical image segmentation. It combines a weak‑to‑strong consistency regularization with a Discriminative Feature Enhancement mechanism and a prompt generator that uses Physical Constraints with a Sliding Window to supply prompts for unlabeled data. Experiments on the ACDC and BHSD datasets show that SSS outperforms prior methods, achieving a 53.15 Dice score on BHSD, a +3.65 improvement over the state of the art.
By Hongjie Zhu, Xiwei Liu, Rundong Xue, Zeyu Zhang, Yong Xu, Daji Ergu, Ying Cai, Yang Zhao
The paper presents the first systematic evaluation of out‑of‑distribution generalization for congenital heart disease (CHD) segmentation, using the ImageCHD cohort as a held‑out target. It compares several segmentation architectures under different training regimes, showing that in‑distribution performance is a poor predictor of cross‑cohort robustness: nnU‑Net drops from 0.77 to 0.51 Dice, while SwinUNETR maintains higher performance at 0.67 Dice. Limited target‑domain adaptation with only 11 labeled ImageCHD cases boosts all SwinUNETR variants above 0.76 Dice, highlighting the importance of explicit cross‑dataset testing.
By Aniketh Vijesh, Shrisharanyan Vasu, Abhijit Ramesh, Clare Pomeroy-Ward, Harikrishnan Anil Maya, Sarin Xavier, Mahesh Kappanayil, Gilad Gressel