arXiv Machine Learning

Interpretable factorization of clinical questionnaires to identify latent factors of psychopathology

arXiv:2312. 07762v3 Announce Type: replace Abstract: Psychiatry research seeks to understand the manifestations of psychopathology in behavior, as measured in questionnaire data, by identifying a small number of latent factors that explain them.

arXiv AI
Jun 10

Dep-LLM: Training-Free Depression Diagnosis via Evidence-Guided Structured Multi-factor with Reliable LLM Reasoning

arXiv:2606. 10796v1 Announce Type: cross Abstract: Automatic Depression Detection (ADD) from clinical interviews is a pivotal task in computational mental health, yet it remains challenging due to two critical obstacles: 1) difficulty in modeling complex but sparsely distributed depression clues within lengthy, multi-topic clinical interviews, leading to superficial and unreliable reasoning; 2) scarcity of labeled data due to clinical privacy, together with high cost of training and fine-tuning, limiting the deployment of supervised ADD systems.

By Yiqing Lyu, Xianbing Zhao, Buzhou Tang, Ronghuan Jiang
arXiv Machine Learning
5d ago

Supervised Deep Multimodal Matrix Factorization for Interpretable Brain Network Analysis

The paper introduces Supervised Deep Multimodal Matrix Factorization (SD3MF), an interpretable framework that extends Symmetric Nonnegative Matrix Tri-Factorization to supervised prediction across populations of multimodal brain graphs. SD3MF learns deep hierarchical factorizations for each modality and a shared latent representation, jointly optimizing graph reconstruction and prediction while enabling data-driven multimodal fusion. Experiments on multimodal connectome datasets demonstrate that SD3MF outperforms strong deep learning baselines such as CNNs and GNNs, providing biologically interpretable insights through community-level interaction matrices.

By Amjad Seyedi, Lifang He, Songlin Zhao, Akwum Onwunta, Nicolas Gillis
arXiv Machine Learning
Jul 23

Non--negative matrix factorization using the \textit{R} package \textsf{nnmf}

arXiv:2607. 20084v1 Announce Type: cross Abstract: Non--negative matrix factorization (NMF) has become an established dimensionality reduction technique for extracting latent structures from non--negative data and has found widespread applications in fields such as bioinformatics, text mining, image analysis, and recommender systems.

By Volkan Sevin\c{c}, Nikolas Kontemeniotis, Theodoros Perdikis, Michail Tsagris
arXiv Machine Learning
Jun 18

Shrinkage priors for Bayesian Substitute Confounders

arXiv:2606. 18535v1 Announce Type: cross Abstract: Multi-cause observational studies contain information about unmeasured confounding through the dependence structure among causes.

By Yordan P. Raykov, Hengrui Luo, Justin D. Strait, Wasiur R. KhudaBukhsh
arXiv Machine Learning
Sep 15

Scalable partial information decomposition for symptom networks via supervised embeddings

The paper introduces ePID, an embedding-based approach that scales partial information decomposition (PID) to large symptom networks by compressing non‑focal symptoms into a low‑cardinality discrete embedding. Using a supervised Agglomerative Conditional Information Bottleneck (ACIB) embedding, ePID accurately recovers source‑unique, remainder‑unique, redundant, and synergistic components for each ordered source‑target pair across 83 real‑world datasets, outperforming 12 other embeddings. Applied to PHQ‑9 and the Interpersonal Reactivity Index, ePID reveals distinct patterns of redundancy and synergy that align with each instrument’s construction, demonstrating its ability to separate overlapping from interaction‑dependent information in symptom networks.

By Cillian Hourican, Eric Dignum, Rick Quax, Debraj Roy