The paper evaluates block-based masked diffusion (BD) as an alternative to autoregressive (AR) models for zero‑shot prediction from longitudinal electronic health records. On the MIMIC‑IV dataset, BD shows a clear trade‑off between quality and efficiency: small‑block configurations retain most of AR’s predictive performance while enabling faster inference, with a representative B=8 setting achieving about 1.43× faster evaluation. Although BD’s generative rollout lags behind AR in most settings, frozen linear probes on BD and AR representations perform nearly identically across clinical prediction tasks, indicating that BD learns comparably informative clinical representations.
By Ashvin Gupta, Joshua Placidi, Brendan Delaney, Alessandra Russo
Masked language modelling (MLM) remains the dominant pretraining objective for transformer encoders on longitudinal electronic health records (EHRs), but reconstructing individual events can overemphasise noisy observations and fails to encourage learning higher‑level patient states. Joint‑Embedding Predictive Architectures (JEPAs), which predict representations in latent space, were tested on MIMIC‑IV data and, while training stably, consistently underperformed standard MLM. The study found that larger target sizes increase prediction error, yet reducing target size does not improve downstream performance, indicating that stable latent prediction alone is insufficient for competitive EHR representation learning and underscoring the difficulty of defining clinically meaningful latent targets for EHR.
By Ashvin Gupta, Brendan Delaney, Alessandra Russo
arXiv:2602. 15159v2 Announce Type: replace Abstract: Electronic health records (EHR) arrive masked.
By Xiao Xiang, David Restrepo, Hyewon Jeong, Yugang Jia, Leo Anthony Celi
arXiv:2607. 22264v1 Announce Type: new Abstract: Autoregressive foundation models trained on tokenized electronic health records (EHRs) can support zero-shot clinical prediction, yet most operate on structured event codes alone, and do not incorporate multiple modalities in a principled way.
By Yuxuan Liu, Joshua Placidi, Jinpei Han, Alfred John Balston, Marek Rei, A. Aldo Faisal
arXiv:2506. 04831v3 Announce Type: replace Abstract: Forecasting how a patient's condition is likely to evolve, including possible deterioration, recovery, treatment needs, and care transitions, could support more proactive and personalized care, but requires modeling heterogeneous and longitudinal electronic health record (EHR) data.
By Chantal Pellegrini, Ege \"Ozsoy, David Bani-Harouni, Matthias Keicher, Nassir Navab
arXiv:2608. 20315v1 Announce Type: new Abstract: Predictive models over structured electronic health records (EHRs) remain central to machine learning for healthcare, but few have jointly emphasized quantitative laboratory information and interpretability with respect to input medical events.
By Jun Ni Du, Lukas Adamek, Maxim Kryukov, Flavio Dormont, Ziv Bar-Joseph, Sven Jager, Brandon Rufino
arXiv:2607. 15447v1 Announce Type: new Abstract: Recent research in clinical machine learning, focusing on outcome predictions in intensive care unit (ICU), has shifted from bespoke supervised models to foundation models, utilising modern representation learning methods.
By Jingteng Li, Alexander Capstick, Louise Rigny, Iona Biggart, Neil J Sebire, Payam Barnaghi
arXiv:2609.37587v1 Announce Type: cross
Abstract: Longitudinal electronic health record (EHR) modeling requires integrating new visits with an expanding patient history. Yet the continual accumulatio...
By Zijie Meng, Xiwei Dai, Yingying Zhang, Jian Wu, Xian Wu, Zuozhu Liu
Mr.Dec is a new Transformer‑decoder model that predicts 30‑day hospital readmission by treating each admission as a chronological sequence of daily multimodal events, integrating Electronic Health Record updates and Chest X‑ray findings. It uses disease‑specific supervised contrastive learning to shape a diagnosis‑aware latent space and preserves day‑level clinical signals that other methods often compress. Experiments on MIMIC‑IV and MIMIC‑CXR datasets show state‑of‑the‑art performance and the model can highlight "Critical Days" for actionable real‑time risk stratification.
By Minjun Kim, Jong Hak Moon
NOAH is a generative transformer that models the entire multimodal patient journey by integrating bidirectional time and a variational latent space to capture continuous, stochastic clinical trajectories. Trained on over 559 million events from 431,000 hospital visits, it processes medical images, time‑series, numeric signals, categorical events, and both structured and unstructured records. The model supports autoregressive forecasting, zero‑shot classification, and counterfactual simulations, yielding strong predictive performance across 15 ICD chapters, 29 comorbidities, and time‑to‑event outcomes.
arXiv:2606. 19651v1 Announce Type: new Abstract: Three-dimensional (3D) brain MRI is central to clinical neurology and neuro-oncology, where generative models could augment under-represented cohorts, simulate disease trajectories, and support privacy-preserving data sharing.
By Max Van Puyvelde, Ibrahim Gulluk, Wim Van Criekinge, Olivier Gevaert
arXiv:2606. 28798v1 Announce Type: new Abstract: Objective: ICD codes are central to reimbursement, research, and population health surveillance, yet automated coding systems often struggle to integrate diagnostic signals from both clinical narratives and structured electronic health record (EHR) variables.
By Chengyuan Liu, Xinyue Zhang, Yao Li, Guanting Chen