arXiv Machine Learning

An Approximate Graph Elicits Detonation Lattice

arXiv:2603. 16524v2 Announce Type: replace-cross Abstract: This study presents a novel algorithm based on graph theory for the precise segmentation and measurement of detonation cells from 3D pressure traces, termed detonation lattices, addressing the limitations of manual and primitive 2D edge detection methods prevalent in the field.

arXiv Machine Learning
Aug 31

TI$^2$PS: A Topology-Informed Inverse Design Framework for Stochastic Multicellular Pattern Formation

The paper introduces TI$^2$PS, a topology-informed inverse design framework that estimates agent-based model parameters to reproduce target multicellular patterns. It combines Betti vectors from topological data analysis with inverse surrogate modeling to address challenges in parameter estimation and topological evaluation under stochastic cell dynamics. Validation on zebrafish pigment pattern formation shows the framework outperforms conventional methods, achieving superior results with only 10% of the training data.

By Kenji Komiya, Andrew Kailiang Jin, Ryo Nishikimi, Kunio Kashino
arXiv Machine Learning
Jun 10

POPSICLE: Benchmark Datasets for Segmentation and Localization in CryoET

arXiv:2606. 10255v1 Announce Type: cross Abstract: Cryo-electron tomography (cryoET) has emerged as a powerful tool in structural and cellular biology by enabling direct visualization of macromolecular structures within intact cells, thereby linking molecular architecture to cellular organization in a native context.

By Jonathan Schwartz, Utz Heinrich Ermel, C. Braxton Owens, Zhuowen Zhao, Ariana Peck, Gus L. W. Hart, Grant J. Jensen, Bridget Carragher, Dari Kimanius
arXiv AI
Sep 15

End-to-End Cell Detection via Instance-aware Graph Modeling

The paper introduces an end‑to‑end framework for detecting and classifying cells in pathology images by jointly modeling visual features and instance‑level interactions. It employs a dynamic graph construction module that builds cell graphs from learnable queries and an instance‑aware graph network that filters and reorganizes features, integrating appearance and relational evidence. Experiments on multiple staining protocols show the method surpasses existing approaches in both detection and classification accuracy.

By Ruochen Liu, Yalin Zheng, Jingxin Liu, Jianfeng Zhang, Shoujun Huang, Dexing Kong, Haofeng Li, Wei Lou
arXiv AI
Sep 28

LapDDPM: Spectral Perturbation Diffusion for Robust Single-Cell Manifold Generation

LapDDPM is a conditional Graph Diffusion Probabilistic Model that generates high‑fidelity, biologically plausible single‑cell RNA sequencing data. It incorporates graph‑based inductive biases and a spectral adversarial perturbation mechanism to enforce robustness against structural noise, effectively acting as a Distributionally Robust Optimization framework. The model extends to spatial transcriptomics and multi‑modal data, and experimental results on datasets such as PBMC3K, Dentate Gyrus, HLCA, Visium, and 10x Multiome show it outperforms state‑of‑the‑art baselines in distribution matching, manifold preservation, and downstream utility.

By Lorenzo Bini, Stephane Marchand-Maillet
arXiv Machine Learning
Aug 11

Beyond Isotropic Assumptions: Continuity-Constrained Segmentation and GPU Morphometry for Nanoscale GBM Analysis

arXiv:2608. 07575v1 Announce Type: cross Abstract: Confocal microscopy of optically cleared and swelled tissue resolves complex biological structures in 3D, but such acquisitions are highly anisotropic: along the under-sampled axial direction the structure can appear discontinuous, hampering reconstruction and automated quantitative analysis.

By Arash Fatehi, Robin Ebbestad, Linus Butt, Hans Blom, Sigrid Lundberg, Hannes Olauson, Hjalmar Brismar, David Unnersj\"o-Jess, Thomas Benzing, Katarzyna Bozek
arXiv Computer Vision
Aug 25

Differentiable Voxelization of Surface Representations

The paper introduces a differentiable voxelization technique that computes gradients of volumetric properties, such as winding numbers, with respect to surface mesh parameters. This method allows efficient optimization of triangle meshes using voxel-based volume samples on a regular grid. The authors demonstrate its utility in applications like resolving mesh intersections, designing manufacturable shapes for bandsaw cutting, and creating near-tiling 3D structures.

By Tobias Djuren, Ugo Finnendahl, Markus Worchel, Hendrik Meyer, Marc Alexa
arXiv AI
Jul 7

From Raw Segmentations to Simulation-Ready Cardiac Meshes: An Automated Framework for Anatomical Reconstruction and Virtual Cohort Generation

arXiv:2607. 02564v1 Announce Type: cross Abstract: Computational models of the human heart are widely used to study electromechanical and fluid-dynamical cardiac function and to support applications such as in silico clinical trials.

By Francesco Fabbri, Martino Andrea Scarpolini, Paolo Ciancarella, Francesco Tudisco, Roberto Verzicco, Alessandro Ricci, Francesco Viola