A multicenter study developed an AI-enabled electrocardiography (AI-ECG) model that predicts vessel-specific hemodynamically significant stenosis using coronary computed tomographic angiography (CCTA) as the reference. The model demonstrated strong discrimination in internal and external cohorts, including normal ECGs, and produced low-, intermediate-, and high-risk strata that correlated with stenosis severity and major adverse cardiovascular events. Calibration, decision curve analyses, and integration with guideline-based pre-test probability showed clinical utility, while waveform and attribution analyses revealed physiologically meaningful ECG features linked to high-risk predictions.
By Yujie Xiao, Qinghao Zhao, Gongzheng Tang, Hao Zhang, Zhuoran Kan, Deyun Zhang, Jun Li, Guangkun Nie, Xiaocheng Fang, Haoyu Wang, Shun Huang, Tong Liu, Jian Liu, Kangyin Chen, Shenda Hong
The study demonstrates that contrastive pre‑training of ECG representations using cardiac magnetic resonance (CMR) imaging data can enhance ECG‑based detection of Chagas disease. By aligning an ECG encoder with a CMR embedding space from 63,193 paired UK Biobank examinations, the authors achieved higher AUROC and sensitivity metrics on CODE‑15%, SaMi‑Trop, and PhysioNet/CinC 2025 Challenge datasets compared to an unaligned baseline. The approach shows that imaging‑supervised ECG representations generalize across different populations and resource‑constrained settings.
By Laura Alvarez-Florez, Daniel Uyterlinde, Samuel Ruip\'erez-Campillo, Lukas P. A. Arts, Folkert W. Asselbergs, Fleur V. Y. Tjong
arXiv:2607. 16323v1 Announce Type: cross Abstract: Electrocardiography (ECG) is an inexpensive, standard-of-care test for cardiac symptoms, but front-line triage often lacks immediate access to definitive imaging such as echocardiography (ECHO) or cardiac magnetic resonance (CMR).
By Alexander Selivanov, Friederike Jungmann, Jan Kehrer, Karl-Ludwig Laugwitz, Eimo Martens, Daniel Rueckert
arXiv:2608. 03597v1 Announce Type: new Abstract: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with increased risks of stroke, heart failure, and mortality.
By Amirhossein Taleshinosrati, Yangyang Wang, Atitaya Phoemsuk, Vahid Abolghasemi, Naser Hossein Motlagh, Sadasivan Puthusserypady, Daniel Teichmann, Abdolrahman Peimankar
The study investigates whether ECG representations derived from a β-variational autoencoder (VAE) can distinguish patients with myocardial scar (LGE+) from those without (LGE-) using routine ECG data. In a cohort of 300 cardiomyopathic patients, the β-VAE achieved an AUC of 0.577 (sensitivity 0.775) with Gradient Boosting, while the foundation ECGx.AI model reached an AUC of 0.686 with Random Forest. Dynamic Time Warping reconstruction errors differed significantly between classes in most leads and improved classification to an AUC of 0.643 with Logistic Regression, suggesting these errors could serve as markers of scar-related ECG changes.
By Shayan Sharifi, Riccardo Treu, Ilaria Gandin, Federico Garoia, Marco Merlo, Giulia Cisotto
arXiv:2608. 14723v1 Announce Type: cross Abstract: Reduced left ventricular ejection fraction (LVEF) is frequently asymptomatic and often detected only after advanced heart failure develops.
By Burcu Ozek, Aruna Mohan, David Vorchheimer, Daniel Weiss, Eyal Kedar, Tamar Sobol, Or Zilbershot, Fatemeh Afghah
arXiv:2605. 29977v2 Announce Type: replace-cross Abstract: High-fidelity ECG interpretation is increasingly reliant on massive foundation models, yet their deployment in clinical edge-care remains hindered by extreme computational demands.
By Dang Nguyen Hong, Nhi Ngoc-Yen Nguyen, Huy-Hieu Pham
arXiv:2607. 07683v1 Announce Type: new Abstract: Electrocardiography (ECG) is one of the most widely used tests for diagnosing cardiovascular disease.
By Shreyasvi Natraj, Cyrus Achtari, Felice Gragnano, Andrea Milzi, Marco Valgimigli, Diego Paez-Granados
arXiv:2609.21755v1 Announce Type: new
Abstract: Emergency department (ED) decision-making relies on heterogeneous clinical information, including patient history, vital signs, laboratory results, and...
By Jinning Liang, Mingcheng Zhu, Tingting Zhu
arXiv:2607. 24035v1 Announce Type: cross Abstract: Explainable AI (XAI) is used to assess whether artificial intelligence models rely on meaningful patterns, yet explanations that appear plausible for individual predictions may systematically misrepresent model behavior.
By Nils Gumpfer, Michael Guckert, Samuel Sossalla, Birgit A{\ss}mus, Jennifer Hannig
arXiv:2608. 05893v1 Announce Type: new Abstract: Electrocardiography (ECG) is one of the most widely used non-invasive tools for diagnosing cardiovascular disease, but transforming multi-lead ECG recordings into reliable clinical reports remains challenging.
By Akanta Das, Tasinul Islam Ahon, Ahmed Mahir Sultan Rumi, Md Mahbubur Rahman, Tausif Amim Shadly, Tanzima Hashem
arXiv:2608.30367v1 Announce Type: new
Abstract: Transformer-based electrocardiogram (ECG) models commonly tokenize waveforms into fixed temporal patches. Though convenient, fixed patching can split h...
By Ahmed Sameh, Nolan Wilson, Max Enderlein, Yogatheesan Varatharajah