One year ago, the AISLE roadmap argued that autonomous laboratories operated as isolated islands and proposed a grassroots network organized around five critical dimensions. The field has since moved faster than anticipated.
Agentic artificial intelligence (AI) systems are beginning to assist, accelerate, and partially automate scientific discovery, performing tasks that span literature synthesis, code generation, data analysis, hypothesis proposal, and model criticism. We argue that this transition is qualitative rather than incremental, and that suitably designed multi-agent systems may evolve from passive computational tools into ``AI scientists'' that can expand the hypothesis-generating and verification capacity of science.
arXiv:2604. 17406v3 Announce Type: replace Abstract: The convergence of large language models and agents is catalyzing a new era of scientific discovery: Agentic Science.
By Xinyu Zhu, Yuzhu Cai, Zexi Liu, Cheng Wang, Fengyang Li, Wenkai Jin, Wanxu Liu, Zehao Bing, Bingyang Zheng, Jingyi Chai, Shuo Tang, Rui Ye, Yuwen Du, Xianghe Pang, Yaxin Du, Tingjia Miao, Yuzhi Zhang, Ruoxue Liao, Zhaohan Ding, Linfeng Zhang, Yanfeng Wang, Weinan E, Siheng Chen
arXiv:2607. 26064v1 Announce Type: cross Abstract: AI systems are becoming autonomous research agents that generate hypotheses, design experiments, and produce discoveries at scales beyond human oversight.
By Belinda Mo
arXiv:2605. 18661v2 Announce Type: replace Abstract: AI-assisted research is crossing a threshold: fully automated systems can now generate research papers for as little as $15, while long-horizon agents can execute experiments, draft manuscripts, and simulate critique with minimal human input.
By Lingdong Kong, Xian Sun, Wei Chow, Linfeng Li, Kevin Qinghong Lin, Xuan Billy Zhang, Song Wang, Rong Li, Qing Wu, Wei Gao, Yingshuo Wang, Shaoyuan Xie, Jiachen Liu, Leigang Qu, Shijie Li, Lai Xing Ng, Benoit R. Cottereau, Ziwei Liu, Tat-Seng Chua, Wei Tsang Ooi
arXiv:2607. 02329v1 Announce Type: new Abstract: Autonomous-research agents have demonstrated end-to-end LLM automation in machine-learning sandboxes where execution provides calibration.
By Haonan Huang
arXiv:2606. 15497v1 Announce Type: new Abstract: The automation of science is a long-standing ambition in the field of AI.
By Yutaro Yamada, Robert Tjarko Lange, Cong Lu, Chris Lu, Shengran Hu, Jakob Foerster, David Ha, Jeff Clune
arXiv:2606. 30246v1 Announce Type: new Abstract: Existing autonomous research agents can support parts of the research process, but most systems still treat research as either an isolated assistant task or a closed workflow.
By Zihan Guo, Zeyi Chen, Zhiyu Chen, Zicai Cui, Shuai Shao, Bo Huang, Zhi Han, Yuanyi Song, Yuan Yuan, Chenxi Zeng, Xiaohang Nie, Zhengxi Yu, Hanwen Zhu, Junwei Liao, Ming Zhou, Yang Li, Yuanjian Zhou, Weinan Zhang
arXiv:2606. 07462v1 Announce Type: new Abstract: As foundation models advance and agent scaffolding becomes increasingly sophisticated, agents have demonstrated remarkable proficiency in complex, long-horizon coding tasks and even autonomous experiment execution.
By Jiayu Wang, Weijiang Lv, Bowen Fu, Jing Fu, Jiayi Song, Lingyu Zhang, Lanxuan Xue, Luodi Chen, Zepeng Xin, Kaiyu Li, Xiangyong Cao
arXiv:2606. 18874v1 Announce Type: new Abstract: AI systems can increasingly automate scientific workflows, but the reasoning that links prior evidence, generated ideas, experiments and final claims often remains implicit inside model inference.
By Zijian Wang, Hanqi Li, Ziyue Yang, Zijian Hu, Shenghan Zuo, Yunzhe Zhang, Da Ma, Danyu Luo, Chenrun Wang, Jing Peng, Tiancheng Huang, Sijia Guo, Huayang Wang, Zichen Zhu, Senyu Han, Yilu Cao, Kai Yu, Lu Chen
arXiv:2607. 05682v1 Announce Type: new Abstract: LLM systems for scientific discovery increasingly assist with ideation, literature synthesis, experiment planning, and report generation, but the first research question they propose can remain difficult to audit: it may sound plausible without exposing the mechanism, falsifier, or assumption that a scientist should inspect.
By Yufeng Wang
arXiv:2606. 01316v1 Announce Type: new Abstract: Scientific discovery demands intelligence, perseverance, and serendipity across vast search spaces.
By Zhe Zhao, Haibin Wen, Yingcheng Wu, Jiaming Ma, Yifan Wen, Jinglin Jian, Jiacheng Ge, Xiangru Tang, Bo An, Ming Yin, Sanfeng Wu, Mengdi Wang, Le Cong