The study examines how multi‑fidelity training—using abundant low‑fidelity data and scarce high‑fidelity labels—affects uncertainty decomposition in atomistic models. By training deep ensembles of mean‑variance MACE models on ANI‑1x, the authors compare high‑fidelity training from scratch with low‑fidelity pretraining followed by fine‑tuning, evaluating aleatoric, epistemic, and total uncertainty under unseen molecular systems and higher‑energy configurations. Results show that pretraining lowers prediction error and improves uncertainty‑based ranking, but does not produce well‑calibrated predictive variances, especially under energy extrapolation, and that fine‑tuning yields a more effective uncertainty‑based acquisition function.
arXiv:2606. 04100v1 Announce Type: new Abstract: Machine learning interatomic potentials (MLIPs) enable efficient and accurate atomistic simulations but depend critically on the quality and diversity of the training data.
arXiv:2609.00488v1 Announce Type: new Abstract: Machine learning interatomic potentials bridge the gap between quantum chemical precision and classical computational speed, enabling molecular dynamic...
Zatom-2 is a multitask generative model for atomistic data that has been pretrained on about five million structures from the OMol25 and OMat24 datasets. It uses a multiscale Transformer with conditional flow matching to support tasks such as generation, structure prediction, and energy/force prediction for both molecules and materials. The model outperforms its predecessor, Zatom-1, on molecular distribution fidelity and benchmark generation tasks, and improves protein backbone designability from 67.8% to 74.8% after finetuning on 2,000 protein domains.
arXiv:2606. 30961v1 Announce Type: cross Abstract: Advances in deep learning architectures and representations have enabled ML-driven chemical property prediction, but state-of-the-art (SOTA) models have remained largely confined to independent codebases and lack support for diverse chemical species.
arXiv:2607. 03513v1 Announce Type: cross Abstract: We present AquaGen, the first all-atom, explicit solvent, periodic-boundary-condition-aware generative model that produces molecular configurations from the Boltzmann distribution at a fraction of the cost of molecular dynamics (MD).
arXiv:2606. 17077v1 Announce Type: cross Abstract: Proton dissociation constants (pKa) are critical for functional molecule discovery and molecular modeling.
arXiv:2607. 14486v1 Announce Type: cross Abstract: Machine-learning force fields (MLFFs) are reliable only near their training distribution, making efficient construction of diverse training sets a major bottleneck for both train-from-scratch and foundation fine-tuning workflows.
The paper proposes pre-training uncertainty estimators on large, diverse materials science datasets to improve uncertainty quantification (UQ) for machine‑learned interatomic potentials (MLIPs). By evaluating these pre‑trained models on both in‑distribution and out‑of‑domain adsorption‑energy predictions, the authors demonstrate that zero‑shot UQ is viable and that fine‑tuning yields strong correlations between predicted uncertainty and actual prediction error, even on challenging datasets. This approach aims to provide foundational UQ models that enable broader, more reliable deployment of MLIPs across chemical space.
arXiv:2606. 02662v1 Announce Type: cross Abstract: Machine learning has accelerated quantum chemistry but is hindered by the prohibitive cost of generating high fidelity training data.
arXiv:2606. 08148v1 Announce Type: cross Abstract: Interatomic potentials (IPs) enable large-scale atomistic simulations beyond the reach of first-principles methods, but their predictive reliability depends critically on the selection of training data, quantified uncertainty, and model expressiveness.
arXiv:2607. 09456v1 Announce Type: new Abstract: Universal machine learning interatomic potentials (uMLIPs) bridge quantum-mechanical accuracy and large-scale molecular dynamics, but the cost of high-accuracy calculations such as r$^2$SCAN limits training to datasets that remain small relative to the open materials space.
BOOM is a new benchmark for evaluating out‑of‑distribution (OOD) molecular property predictions in machine learning. It provides chemically‑informed tests across common property prediction tasks and assesses over 150 model‑task combinations. The study shows that current models, including chemical foundation models, struggle to generalize OOD, with the best model still exhibiting three times higher error than in‑distribution predictions.