EHR-MPC: Inference-Time Control for Sepsis Treatment with Generative Patient Digital Twins
arXiv:2607. 08793v1 Announce Type: cross Abstract: Sepsis is a leading cause of mortality, yet optimal treatment policies remain contested.
arXiv:2607. 21403v1 Announce Type: new Abstract: Mobile-health interventions increasingly use online learning and decision making algorithms to personalize when to nudge users toward healthier behavior, but a poorly designed algorithm can burden and disengage participants.
arXiv:2607. 08793v1 Announce Type: cross Abstract: Sepsis is a leading cause of mortality, yet optimal treatment policies remain contested.
arXiv:2606. 14604v1 Announce Type: cross Abstract: Wearable devices and smartphones generate rich behavioural time series that can support proactive health interventions, yet systematic comparisons of modern forecasting architectures for these data are lacking.
arXiv:2606. 17405v1 Announce Type: new Abstract: Clinical decision support AI systems (CDSASs) must adapt to evolving patient conditions in real-time while adhering to strict safety constraints.
The paper introduces PAFIR, a Personalized and Adaptive Feature selection framework that treats feature selection as a reinforcement learning problem over longitudinal multimodal health data. PAFIR jointly models structural dependencies among assessment variables and temporal dynamics in wearable-derived physical activity data, learning adaptive selection policies across repeated study visits using reward signals from sparse fall incidence outcomes. Applied to the Physio Feedback Exercise Program (PEER) trial, PAFIR outperforms state‑of‑the‑art baselines by capturing longitudinal and structural patterns of feature relevance, enabling dynamic, subject‑specific feature selection for more timely fall prevention strategies.
arXiv:2608. 10915v1 Announce Type: new Abstract: After an older adult misses a medication dose, a software agent can send another reminder and an embodied agent can bring the medication.
arXiv:2606. 16721v1 Announce Type: new Abstract: Medical diagnosis and treatment are dynamic processes in which patient states evolve over time and clinical interventions alter future outcomes.
arXiv:2607. 13940v1 Announce Type: new Abstract: Personal health management unfolds over repeated encounters, yet most health AI systems treat each request in isolation.
arXiv:2601. 15353v2 Announce Type: replace-cross Abstract: Reinforcement learning (RL) has achieved remarkable success in real-world decision-making across diverse domains, including gaming, robotics, online advertising, public health, and natural language processing.
Alzheimer's disease (AD) progression is highly heterogeneous and is typically observed through sparse and irregular longitudinal data, posing challenges for prediction and personalised monitoring. Existing machine learning approaches have improved AD prediction using multimodal data, yet often focus on static classification or cohort-level risk estimation, providing limited support for subject-specific modelling and uncertainty-aware reasoning.
arXiv:2606. 02812v1 Announce Type: new Abstract: Modeling patient trajectories from longitudinal electronic health records (EHRs) requires reasoning over sparse, noisy, and long-context multimodal sequences.
DeMMO is an interpretable framework that models longitudinal digital mobility outcomes (DMOs) across multiple diseases and outcomes using multi-task learning. It introduces a cross-disease, cross-outcome relation-learning mechanism that learns signed relationships from longitudinal DMO coefficient matrices, allowing selective information sharing even when disease cohorts lack shared participants. Evaluated on the Mobilise‑D dataset, DeMMO outperforms nine strong baselines and identifies reliable longitudinal DMO patterns for clinical validation.
arXiv:2606. 09671v1 Announce Type: cross Abstract: Alzheimer's disease (AD) progression is highly heterogeneous and is typically observed through sparse and irregular longitudinal data, posing challenges for prediction and personalised monitoring.