The paper presents a study on adaptive chemotherapy control using deep reinforcement learning (DRL) to address tumor heterogeneity and drug resistance. Closed‑loop DRL dosing policies—continuous (TD3) and discrete (DQN)—are trained on a high‑dimensional heterogeneous tumor model and benchmarked against a Pontryagin's Maximum Principle (PMP) open‑loop solution. Across a 100‑patient virtual cohort with ±10% parameter perturbations, TD3 achieves higher average tumor reduction, while DQN offers tighter inter‑patient dosing consistency, highlighting an efficacy‑consistency trade‑off. The work assumes full observation of tumor subpopulations, noting that clinical translation will require handling sparse, noisy measurements.
arXiv:2609.06667v1 Announce Type: new Abstract: Adaptive dosing requires policies that reduce tumor burden without excessive toxicity. Learned dosing policies are typically judged against historical...
arXiv:2607. 13877v1 Announce Type: new Abstract: Brain tumor progression exhibits spatially heterogeneous growth, patient-specific treatment response, and complex interactions with surrounding anatomy, making accurate long-term prediction challenging.
arXiv:2607. 16916v1 Announce Type: new Abstract: Bladder cancer treatment requires personalized and adaptive decision-making, particularly for recurrent disease, where treatment effectiveness changes across successive clinical episodes.
arXiv:2606. 10376v1 Announce Type: new Abstract: Cancer treatment is at the core a sequential decision-making problem with partial observability, latent patient heterogeneity, and explicit constraints on the budget for medical measurements.
arXiv:2606. 01028v1 Announce Type: new Abstract: Medical treatment recommendation poses several challenges to reinforcement learning (RL): patient physiology evolves in continuous time, measurements and interventions are performed at irregular intervals, and treatment effects vary substantially across individuals.
arXiv:2606. 17405v1 Announce Type: new Abstract: Clinical decision support AI systems (CDSASs) must adapt to evolving patient conditions in real-time while adhering to strict safety constraints.
The paper introduces MedGym, a benchmark environment for dynamic medical treatment recommendation that models patient evolution in continuous time using Physics-Informed Neural Networks. It addresses gaps in existing reinforcement learning (RL) approaches by allowing evaluation of RL methods under irregular measurement intervals, personalized treatment responses, and safety considerations. MedGym enables direct comparison between discrete-time and continuous-time RL methods and supports clinically relevant metrics such as personalization and trajectory-level safety.
PerturbRx is a treatment‑conditioned representation learning framework that learns latent transitions induced by drug interventions. It trains a drug‑ and dose‑conditioned transition predictor using control and treated single‑cell populations, then applies this predictor to pretreatment patient profiles to generate response features without needing post‑treatment data. On TCGA and patient‑derived xenograft benchmarks, PerturbRx outperforms other methods, demonstrating the value of perturbation‑pretrained latent transitions for patient‑level drug‑response prediction.
The paper introduces Multi-step Proximal Policy Improvement (MPI), a method that refines offline reinforcement learning policies through sequential re-centered proximal steps. By viewing policies as a probability manifold, MPI interprets a wide range of offline actor objectives as a single proximal policy improvement step and extends this to multiple steps for controlled policy improvement beyond the behavior distribution. Experiments on D4RL benchmarks demonstrate that a few MPI refinements enhance strong offline baselines such as TD3+BC, ReBRAC, and IQL, while diagnostics clarify the benefits of re-centered refinement over fixed-objective scheduling and highlight critic error limitations.
arXiv:2607. 16177v1 Announce Type: new Abstract: Reinforcement learning (RL) has recently emerged as a promising feedback control strategy for nonlinear and complex dynamical systems.
arXiv:2603. 09344v3 Announce Type: replace Abstract: Offline reinforcement learning (RL) enables data-efficient and safe policy learning without online exploration, but its performance often degrades under distribution shift.
arXiv:2606. 01051v1 Announce Type: new Abstract: Dynamic medical treatment requires deciding treatment intensity and intervention timing, while patient states evolve continuously and adverse events may occur between clinical interactions.