arXiv AI

Faithful by Design: Evaluating and Improving LLM-Generated Clinical Trial Summaries for Multi-Stakeholder Audiences

arXiv:2607. 09932v1 Announce Type: cross Abstract: Large language models are increasingly used to summarize clinical trial results for healthcare providers, patients, and payers, but their tendency to hallucinate poses significant risks in this high-stakes context.

arXiv AI
Sep 15

A primer on evaluation methods for large language models in healthcare

arXiv:2609.14819v1 Announce Type: cross Abstract: Large language models (LLMs) have a growing range of applications in medicine, and their evaluation is critical for ensuring they provide benefit and...

By Suzannah E McKinney, Phuc Vu, Samuel A Justice, Christopher Humphries, Alyssa Pradhan, Timothy J Keyes, Bernardo C Bizzo, Keith J Dreyer, Sarah F Mercaldo, James M Hillis
arXiv AI
Aug 28

Evaluating AI Generated Summaries for Cancer Patients

The study evaluates AI-generated summaries for cancer patients using a dual assessment framework that includes human experts and LLM-as-a-judge. Human domain experts—oncology clinicians and patient-facing care staff—assess summary quality on accuracy, clinical relevance, and readability. The research identifies limitations such as omissions and minor inaccuracies, which are then used to iteratively refine prompts, grounding, and safety guardrails.

By Muhammad Aurangzeb Ahmad, Kim Shyu, Leon Oliver, Fergus Sleight, Paul Landau
arXiv Computation and Language
Aug 27

Retrieval-Augmented Agentic Rubric Generation for Reliable Medical Response Evaluation

The paper introduces a retrieval‑augmented multi‑agent framework that automatically generates instance‑specific evaluation rubrics for medical language models. By retrieving authoritative medical evidence, decomposing it into atomic facts, and combining these with user interaction constraints, the system produces fine‑grained criteria that outperform GPT‑4o on HealthBench and LLMEval‑Med. The generated rubrics also guide response refinement, improving medical LLM output quality by 9.2%.

By Yinzhu Chen, Abdine Maiga, Hossein A. Rahmani, Emine Yilmaz
arXiv AI
Aug 25

SDoH-Aware Narrative Anchoring Bias in Medical LLMs for Trustworthy Clinical Decision Support

The paper investigates how medical large language models (LLMs) may exhibit narrative anchoring bias when presented with the same clinical case in different patient voices. Using the NarrativeShield SDoH MedQA dataset, the authors evaluate three Qwen2.5 instruction‑tuned LLMs (1.5B, 3B, 7B) on 300 clinical cases, reporting metrics such as persona‑level accuracy, counterfactual consistency, correct consistency, and narrative sensitivity error. The 7B model achieves the highest accuracy (56.33 %) and correct consistency (40.33 %), yet narrative sensitivity errors remain substantial (31.67 %).

By Ahnaf Atef Choudhury, Ramkrishna Saha
arXiv Machine Learning
Sep 25

Language Specificity vs. Domain Diversity: Benchmarking Transformers for Bangla Medical NER

This study benchmarks transformer models for Bangla medical named entity recognition (NER), comparing BanglaBERT, multilingual BERT (mBERT), XLM‑RoBERTa, and GPT‑4o mini under zero‑shot and few‑shot prompting. Across a full test set of 3,179 samples, fine‑tuned XLM‑RoBERTa achieves a new state‑of‑the‑art F1‑score of 0.5959, while BanglaBERT lags with 0.4937, suggesting that domain diversity outweighs language specificity. The analysis shows high performance on Medicine and Specialist entities (F1 > 0.83) but lower accuracy on Symptoms (F1 0.4367), and demonstrates that fine‑tuned transformers outperform prompt‑only approaches by a factor of 3.76.

By Rakib Abdullah, Md. Maruful Islam Maruf
arXiv AI
Aug 13

A corpus-specific clinical RAG system matches or outperforms newer frontier LLMs on HealthBench

arXiv:2608. 12138v1 Announce Type: cross Abstract: General-purpose large language models (LLMs) have recently been reported to match or exceed specialized clinical AI tools on medical benchmarks, but such comparisons draw on a narrow set of systems and on benchmarks developed largely in high-income settings.

By Praveen Reddy, Charuta Mandke, Suvrankar Datta, Sarah Khan, Siddharth Reddy Anthireddy, Shitij Arora, Vishal Singh
arXiv AI
3d ago

Defining and Categorising Human-AI Interactions in Clinical Trials: A Multidimensional Human-AI Classification Approach

The paper introduces a multidimensional framework for classifying human‑AI interactions (HAIIs) in clinical trials, categorising interactions by AI tasks, human‑AI relationships, interaction configurations, and interacting human groups. It evaluates the framework by applying it to 15 trials, with categorisation performed by both human reviewers and large language model classifiers. The study demonstrates that LLMs can assist in categorisation while highlighting the continued need for human judgment when trial records are incomplete or ambiguous.

By Sandra Woolley, Tim Collins, Khalid Khattak, Illia Chernomorets, Ariane Arevalo, Chris Richardson