Flexible Flows for Biological Sequence Design
arXiv:2606. 10543v1 Announce Type: cross Abstract: Designing functional biological sequences requires navigating vast discrete spaces under strict evolutionary and biophysical constraints.
arXiv:2606. 20084v1 Announce Type: new Abstract: Data editing with generative methods typically requires differentiable objectives and gradient-based search.
arXiv:2606. 10543v1 Announce Type: cross Abstract: Designing functional biological sequences requires navigating vast discrete spaces under strict evolutionary and biophysical constraints.
arXiv:2601. 14430v2 Announce Type: replace-cross Abstract: Controlling generative models is computationally expensive.
arXiv:2509. 26405v2 Announce Type: replace Abstract: We introduce InVirtuoGen, a discrete flow generative model for fragmented SMILES for de novo and fragment-constrained generation, and target-property/lead optimization of small molecules.
arXiv:2604. 27147v3 Announce Type: replace-cross Abstract: In generative modeling, we often wish to produce samples that maximize a user-specified reward such as aesthetic quality or alignment with human preferences, a problem known as \textit{guidance}.
arXiv:2607. 23408v1 Announce Type: new Abstract: Expensive black-box optimization is ubiquitous in science and engineering, where function evaluations are costly and the evaluation budget is limited.
arXiv:2607. 18755v1 Announce Type: new Abstract: Flow-based models have established state-of-the-art performance in generative modeling across domains, but are hard to interpret due to their complex latent embeddings.
arXiv:2607. 02637v1 Announce Type: cross Abstract: Recent generative models can produce high-quality synthetic images, offering scalable training training data for data-hungry models.
arXiv:2601. 22495v2 Announce Type: replace Abstract: Fine-tuning flow matching models is a central challenge in settings with limited data, evolving distributions, or computational constraints.
arXiv:2606. 07760v1 Announce Type: new Abstract: Understanding cellular phenotypes and how they respond to perturbations is critical for disease biology and therapeutic design.
arXiv:2605. 00182v3 Announce Type: replace Abstract: Proteins are shaped by gradual evolution under biophysical and functional constraints.
arXiv:2603. 14504v2 Announce Type: replace-cross Abstract: Optimizing the noise samples of diffusion and flow models is an increasingly popular approach to align these models to target rewards at inference time.
arXiv:2603. 28762v2 Announce Type: replace-cross Abstract: Modern Text-to-Image (T2I) diffusion models have achieved remarkable semantic alignment, yet they often suffer from a significant lack of variety, converging on a narrow set of visual solutions for any given prompt.