arXiv:2603. 14504v2 Announce Type: replace-cross Abstract: Optimizing the noise samples of diffusion and flow models is an increasingly popular approach to align these models to target rewards at inference time.
arXiv:2606. 09635v1 Announce Type: cross Abstract: Ensuring the reliability of Large Language Models (LLMs) under distribution drift requires inference-time adaptation.
arXiv:2606. 18066v1 Announce Type: new Abstract: We introduce the Noise-Tilted Reverse Kernel (NTRK), a reward-guided diffusion sampler that injects reward gradients through the noise term, leaving the pretrained reverse kernel unchanged and requiring only a single sample per step.
arXiv:2604. 17415v3 Announce Type: replace-cross Abstract: Reward-based fine-tuning steers a pretrained diffusion or flow-based generative model toward higher-reward samples while remaining close to the pretrained model.
Diffusion models have strong generative capabilities. However, their maximum likelihood training objective only focuses on reconstructing the data distribution, making it difficult to align with specific preferences.
arXiv:2509. 26405v2 Announce Type: replace Abstract: We introduce InVirtuoGen, a discrete flow generative model for fragmented SMILES for de novo and fragment-constrained generation, and target-property/lead optimization of small molecules.
arXiv:2604. 27147v3 Announce Type: replace-cross Abstract: In generative modeling, we often wish to produce samples that maximize a user-specified reward such as aesthetic quality or alignment with human preferences, a problem known as \textit{guidance}.
arXiv:2608. 03929v1 Announce Type: new Abstract: Aligning diffusion models with human preferences usually relies on a sparse terminal reward evaluated on the final generated samples, presenting a severe temporal credit-assignment challenge across the multi-step denoising process.
arXiv:2607. 00691v1 Announce Type: new Abstract: Black-box optimization is a fundamental science and engineering tool that makes it possible to optimize objectives without gradient information.
arXiv:2606. 01220v1 Announce Type: cross Abstract: Generating molecules that simultaneously satisfy drug-like properties and conform to the 3D structure of a target protein is a core challenge in structure-based drug design (SBDD).
arXiv:2603. 12893v2 Announce Type: replace-cross Abstract: Reinforcement learning (RL) has become a standard technique for post-training diffusion-based image synthesis models, as it enables learning from reward signals to explicitly improve desirable aspects such as image quality and prompt alignment.
arXiv:2607. 00486v1 Announce Type: cross Abstract: Diffusion models are highly effective at modeling complex data distributions, including images and text.
arXiv:2601. 14430v2 Announce Type: replace-cross Abstract: Controlling generative models is computationally expensive.