arXiv AI

Enhancing In-Hospital Mortality Prediction Using Multi-Representational Learning with LLM-Generated Expert Summaries

arXiv:2411. 16818v2 Announce Type: replace-cross Abstract: To evaluate a multi-representational framework in which large language model (LLM)-generated expert summaries of intensive care unit (ICU) notes are fused with physiology for in-hospital mortality (IHM) prediction, and to determine how much of the resulting gain is non-redundant with the notes themselves.

arXiv AI
2d ago

Clinical Note Bloat Reduction for Efficient LLM Use

The paper introduces TRACE, a method that removes duplicated text—known as note bloat—from clinical notes by leveraging EHR metadata and frequency-based de‑duplication. Across 5.3 million notes from diverse patient cohorts, TRACE eliminated 47.3 % of chart text while preserving information extraction and prediction performance, with only 0.3–6.6 % of removed content being author‑generated. The authors project that applying TRACE could yield net savings of $1.00 M to $13.58 M over three years at a large academic center, depending on model pricing schemes.

By Jordan L. Cahoon, Chloe Stanwyck, Asad Aali, Rachel Madding, Sulaiman S. Somani, Emma Sun, Yixing Jiang, Renumathy Dhanasekaran, Emily Alsentzer
arXiv Machine Learning
Aug 19

MultiSigBERT: Beyond Survival Analysis through Multimodal and Sequential Modeling in Oncology

MultiSigBERT is a unified framework that performs multimodal sequential survival modeling in oncology by integrating narrative clinical reports, numerical measurements, and structured variables. The method converts free-text reports into sentence embeddings, compresses them with modality-specific PCA, and concatenates them with structured covariates to create joint temporal trajectories. These trajectories are encoded using the Signature transform from Rough Paths theory, and the resulting high-dimensional features are fed into a LASSO-regularized Cox model, achieving a concordance index of 0.743 on an independent test set of over 2,500 patients.

By Paul Minchella, St\'ephane Chr\'etien, Guillaume Metzler, Lo\"ic Verlingue, R\'emi Vaucher
arXiv Machine Learning
Jul 20

LLM4EHR: Aligning Clinical Time Series with Medical Event Sequences via Large Language Models

arXiv:2607. 15447v1 Announce Type: new Abstract: Recent research in clinical machine learning, focusing on outcome predictions in intensive care unit (ICU), has shifted from bespoke supervised models to foundation models, utilising modern representation learning methods.

By Jingteng Li, Alexander Capstick, Louise Rigny, Iona Biggart, Neil J Sebire, Payam Barnaghi
arXiv AI
Jun 30

Primary ICD Category Prediction using LLM-based Probing

arXiv:2606. 28798v1 Announce Type: new Abstract: Objective: ICD codes are central to reimbursement, research, and population health surveillance, yet automated coding systems often struggle to integrate diagnostic signals from both clinical narratives and structured electronic health record (EHR) variables.

By Chengyuan Liu, Xinyue Zhang, Yao Li, Guanting Chen
arXiv Computation and Language
Sep 22

LLMs Anchor on Chief Complaint and Fail to Integrate Evidence in Sequential Clinical Triage

The study evaluates large language models (LLMs) on sequential emergency department triage, where acuity labels are predicted from progressively longer nurse‑patient conversations. Six LLMs were tested at five checkpoints on simulated and physician‑authored dialogues, showing a decline from moderate‑to‑substantial agreement on full records to only fair‑to‑moderate agreement at each checkpoint. The models consistently anchor on chief complaint exchanges and fail to integrate later evidence, yielding low agreement with clinicians (QWK 0.295 vs. 0.887‑0.929) and concentrating predictions on ESI‑2 and ESI‑3. whyItMatters":"The findings reveal that LLMs, despite strong offline performance, cannot reliably handle the sequential nature of real‑time triage, highlighting a critical gap for safe deployment in emergency settings."

By Dipankar Srirag, Haokai Zhao, Ashutosh Kumar, Eleanor Hopper, Michael Dalton, Quoc Dung Nguyen, Aditya Joshi, Salil S. Kanhere, Padmanesan Narasimhan
arXiv AI
Aug 28

Evaluating AI Generated Summaries for Cancer Patients

The study evaluates AI-generated summaries for cancer patients using a dual assessment framework that includes human experts and LLM-as-a-judge. Human domain experts—oncology clinicians and patient-facing care staff—assess summary quality on accuracy, clinical relevance, and readability. The research identifies limitations such as omissions and minor inaccuracies, which are then used to iteratively refine prompts, grounding, and safety guardrails.

By Muhammad Aurangzeb Ahmad, Kim Shyu, Leon Oliver, Fergus Sleight, Paul Landau