arXiv:2606. 01316v1 Announce Type: new Abstract: Scientific discovery demands intelligence, perseverance, and serendipity across vast search spaces.
arXiv:2607. 13220v1 Announce Type: new Abstract: Most AI-for-science systems focus on scaling a single reasoning process through better models, larger context windows, long-horizon agentic execution, or digital co-scientists working with one principal user.
The paper introduces ScientistTwo, a fully autonomous multi‑agent framework that takes a scientific problem, establishes baselines, generates hypotheses, and coordinates specialized agents to conduct an end‑to‑end discovery cycle without human intervention. It rigorously tests and refines its methods through automated experiments, ablation studies, and a closed‑loop peer‑review engine. Benchmarking against top conferences (ICLR, ICML, NeurIPS) shows that ScientistTwo produces expert‑level, publishable papers and codebases that outperform human state‑of‑the‑art models and receive higher review ratings under automated AI review.
The paper extends Co‑Scientist, a Gemini‑based multi‑agent system, and validates it in real‑world scientific settings. In materials science it designed a safe precursor route for MXenes and achieved single‑attempt growth of monolayer MoS₂, MoSe₂, and WS₂. In biology it predicted swarming phenotypes of engineered E. coli, and in computer science it discovered a superior inference‑time scaling architecture for HealthBench. A double‑blind study with 30 experts showed that Co‑Scientist’s reliability modules reduce hallucination and plagiarism while improving research safety.
arXiv:2608. 13558v1 Announce Type: new Abstract: Recent advances in foundation models have enabled AI scientists to automate increasingly complete research workflows, from hypothesis generation and code execution to manuscript preparation.
ASI‑Bench is a new benchmark that evaluates AI systems on their ability to conduct innovative exploration and autonomous scientific research across 11 domains, using 60 project‑level tasks. It progressively removes human methodological guidance to test whether AI can independently select methods, execute research, and produce verifiable results. Results from 18 state‑of‑the‑art agent–model configurations show a sharp performance drop when guidance is reduced, indicating current systems still rely heavily on human input.
arXiv:2609.15973v1 Announce Type: new Abstract: Foundation models have progressed from learning and reasoning over existing knowledge, to increasingly learning through action, tool use, and outcome f...
OpenDiscoveryTrace is a public dataset of 558 complete AI scientific agent trajectories that records the reasoning process—thoughts, tool calls, observations, errors, revision triggers, and confidence—across 124 scientific tasks in drug discovery, materials science, genomics, and literature analysis. The dataset includes seven models (three frontier models and four open‑weight models) and 60 live‑retrieval variants, providing a balanced view of performance and error patterns. Pilot analysis shows that process traces reveal behavioral differences invisible to output‑only evaluation, such as differing error rates and types among frontier models.
Eureka is a task‑conditioned Meta‑Agent architecture that transforms long‑horizon scientific tasks into dynamic obligation graphs with explicit acceptance semantics. During execution it constructs Macro‑Agents equipped with specialized state, memory, operators, tools, verifiers, and local topology, using receding‑horizon planning, architecture promotion, and minimal‑sufficient compilation. The system demonstrates strong empirical performance, completing all 170 recursive tasks, generating 3,948 certificates without false acceptances, and achieving significant reductions in input size, recomputation, and consistent serialization across 16,000 concurrent executions.
OpenAI4S is an open‑source scientific research agent that treats code as action and science as sessions, combining a persistent computing runtime with structured session management. It uses tool calls for orchestration, executes code cells in persistent Python and R kernels, and records an append‑only Action Ledger, per‑cell execution logs, versioned artifacts, environment snapshots, and workspace checkpoints to preserve provenance and enable session recovery, branching, and extension. Evaluated on 36 research scenarios—including retrosynthesis, molecular dynamics, and protein design—OpenAI4S achieved a higher overall score (7.83) than a general‑purpose coding harness, especially on long‑horizon, computation‑intensive workflows, though reproducibility remains an open challenge. whyItMatters":"The system demonstrates that persistent execution coupled with session‑level provenance can enhance the reliability of AI‑assisted scientific workflows, as evidenced by its superior performance across diverse research scenarios."
arXiv:2607. 15079v1 Announce Type: new Abstract: Understanding the brain increasingly depends on integrating evidence across scales, modalities, and disciplines.
arXiv:2607. 16038v1 Announce Type: new Abstract: Scientific work increasingly spans heterogeneous artifacts -- papers, code, datasets, scientific file formats, model outputs, figures, manuscripts, and team decisions -- yet general-purpose AI assistants rarely preserve these objects as a coherent, auditable research state.
La Agente ’Optima is an agentic framework that builds and manages Bayesian optimization campaigns for self‑driving laboratories, separating large language model reasoning from campaign execution. It maintains a persistent optimization state, allowing consistent repetitive loops and auditable decisions, and only returns control to the agent when interpretation or revision is needed. In tests on digital discovery tasks and physical platforms, it corrected measurement failures, improved yields, and recommended formulation changes, outperforming human‑directed campaigns in cost and material usage.