Synthetic Hospital is an open, fully synthetic longitudinal electronic health record benchmark created from public medical education material. It contains 1,268 patients and 5,602 encounters, with every diagnosis, finding, and temporal relation grounded in standard ontologies and traceable back to its source. Physicians could not reliably distinguish its records from real charts, and current frontier AI models perform significantly below human experts on tasks such as reconstructing problem lists and summarizing charts.
By Christine Park, Valerie Chen, Tim Dettmers
arXiv:2606. 18613v1 Announce Type: cross Abstract: The most plausible near-term role of medical LLMs is to assist rather than replace physicians, yet current evaluations often test isolated capabilities: clinical knowledge, EHR system interaction, or patient communication.
By Tianming Du, Peijie Yu, Sihan Shang, Danli Shi, My Linh Nguyen, Shengbo Gao, Guangyuan Li, Yinghong Yu, Yan Jiang, Qianlong Zhao, Behzad Bozorgtabar, Shaoxiong Ji, Jiazhen Pan, Daniel Rueckert, Jiancheng Yang
arXiv:2607. 09322v1 Announce Type: new Abstract: In this work, we introduce LongMedBench, a real-world EHR-based benchmark for long-horizon clinical decision-making.
By Yanzhen Chen, Zihan Xu, Xiaocheng Zhang, Zhiting Fan, Weiqi Zhai, Hongxia Xu, Zuozhu Liu
arXiv:2606. 17474v1 Announce Type: cross Abstract: Large language models (LLMs) are increasingly considered for use in clinical consultation tasks, yet most medical evaluations remain static, single-turn, or narrowly outcome-based, limiting their ability to reflect the sequential, uncertain, and interactive nature of real-world care.
By Jiahui Niu, Huizi Yu, Wenkong Wang, Guangxin Dai, Jingxian He, Xiang Li, Zhiying Liang, Xinxin Lin, Kent CY So, Bryan YP Yan, Yun Kwok Wing, Yanqiu Xing, Xin Ma, Lizhou Fan
arXiv:2609.39371v1 Announce Type: new
Abstract: In hospital workflows, electronic health records (EHRs) are often noisy, and may not contain the evidence needed to confirm events or measurements refe...
By Yitong Qiao, Yancheng Jin, Lei Liu, Yue Shen, Jian Wang, Jinjie Gu, Zhixuan Chu
arXiv:2608. 07796v1 Announce Type: new Abstract: Large language models perform strongly on medical knowledge benchmarks, but reliable clinical deployment requires agents to conduct defensible investigations over heterogeneous, longitudinal records: determining what evidence is needed, retrieving and reconciling structured and free-text data, grounding conclusions in verifiable evidence, and deferring cases that cannot be resolved reliably.
By Veronica Chatrath, Bryan Zhu, George Pu, Jingxuan Fan, Apaar Shanker, Varun Ursekar, Anahita Sharma, Jason Qin, Keqi Han, Soham Dinesh Tiwari, Soham Dan, Vijay Kalmath, Yuan Li, Daniel Yue Zhang, Chenguang Wang, Zainab Doctor, Zhijun Yin, Nigam H. Shah, Yuan Xue
EHR2Trace is a system that transforms electronic health records from multiple sources into a standardized, traceable event format suitable for training and evaluating patient world models and clinical agents. It links each event to its original record, separates the event time from the time the information became available, and distinguishes between medication orders, dispensing, and administration. The tool supports both OMOP and MEDS data models, includes automated validation, and was tested on three clinical datasets, converting 846.4 million events and detecting all injected faults.
By Xinye Yang, Yuli Wang, Cheng Ting Lin, Harrison Bai
arXiv:2409. 07314v3 Announce Type: replace-cross Abstract: While Large Language Models (LLMs) achieve superhuman performance on standardized medical licensing exams, these static benchmarks have become saturated and increasingly disconnected from the functional requirements of clinical workflows.
By Praveenkumar Kanithi, Cl\'ement Christophe, Marco AF Pimentel, Tathagata Raha, Prateek Munjal, Nada Saadi, Hamza A Javed, Svetlana Maslenkova, Nasir Hayat, Ronnie Rajan, Shadab Khan
arXiv:2609.13543v1 Announce Type: new
Abstract: LLM agents are predominantly benchmarked on short, single-task trajectories, yet real deployments run for hours under contention, surfacing a different...
By Grace Chang Yuan, Xiaoman Zhang, Sung Eun Kim, Luyang Luo, Pranav Rajpurkar
arXiv:2509. 02594v3 Announce Type: replace-cross Abstract: Evaluating large language models (LLMs) on their ability to generate high-quality, accurate, situationally aware answers to clinical questions requires going beyond conventional benchmarks to assess how these systems behave in complex, high-stakes clinical scenarios.
By Sandhanakrishnan Ravichandran, Shivesh Kumar, Rogerio Corga Da Silva, Miguel Romano, Reinhard Berkels, Michiel van der Heijden, Olivier Fail, Valentine Emmanuel Gnanapragasam
arXiv:2607. 25485v1 Announce Type: new Abstract: Health AI is evolving from answering questions to agentic systems that converse with patients, reason about health records, and act on their behalf.
By Korosh Vatanparvar, Ashutosh Joshi, Maria Xenochristou, Mohammad Abuzar Hashemi, Prasad Kasu, Deepak Bansal, Daniel Lopez-Martinez, Anchal Nema, Ramya Ganesan, Will Kimbrough, Alex Woody, Yadunandana Rao, Dilek Hakkani-Tur, Wilko Schulz-Mahlendorf
arXiv:2601. 23049v2 Announce Type: replace Abstract: Medical calculators are fundamental to quantitative, evidence-based clinical practice.
By Yakun Zhu, Yutong Huang, Shengqian Qin, Zhongzhen Huang, Shaoting Zhang, Xiaofan Zhang