Where Physics Meets Privacy: Federated PINNs for Privacy-Preserving Brain Tumor Biomechanical Modeling

Brain tumors such as glioma, meningioma, and pituitary adenoma alter the mechanical behavior of soft brain tissue, yet common diagnostic methods rely on static imaging that cannot capture tumor growth, tissue displacement, or changes in stiffness over time. Deep learning models for this task typically require pooling patient data at one site, which conflicts with privacy rules such as GDPR and HIPAA and limits generalization across institutions, a challenge that is pronounced in neuro oncology given patient diversity.

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