arXiv AI
Aug 6

Memorization in Large Language Models in Medicine: Prevalence, Characteristics, and Implications

arXiv:2509. 08604v5 Announce Type: replace-cross Abstract: Large Language Models (LLMs) have demonstrated significant potential in medicine, with many studies adapting them through continued pre-training or fine-tuning on medical data to enhance domain-specific accuracy and safety.

By Anran Li, Lingfei Qian, Mengmeng Du, Yu Yin, Yan Hu, Zihao Sun, Yihang Fu, Hyunjae Kim, Erica Stutz, Xuguang Ai, Qianqian Xie, Rui Zhu, Jimin Huang, Yifan Yang, Siru Liu, Yih-Chung Tham, Lucila Ohno-Machado, Hyunghoon Cho, Zhiyong Lu, Hua Xu, Qingyu Chen
arXiv AI
Oct 1

Sense and Sensitivity: Benchmarking LLM Clinical Triage Recommendations with Physician Experts

The paper introduces a benchmark of over 6,000 clinical triage scenarios, 7,000 physician annotations, and 225,000 large language model (LLM) responses to assess how LLMs perform under realistic variations in clinical text. The study finds that LLMs tend to recommend unnecessary care more often than physicians, especially when the input text is perturbed, and that LLM recommendations are more sensitive to gender and tone changes than human recommendations. These findings underscore the importance of deployment‑oriented evaluations that reflect expert physician behavior.

By Abinitha Gourabathina, Haoran Zhang, Yuexing Hao, Walter Gerych, Marzyeh Ghassemi
arXiv Machine Learning
Oct 12

Hidden Data Challenges in Clinical Machine Learning

The paper highlights hidden data challenges in clinical machine learning, focusing on how commonly reused preprocessing pipelines for electronic health records embed assumptions about data availability, episode definitions, and missingness. Using MIMIC-IV, the authors identify violations in temporal, semantic, and population alignment—leading to temporal leakage, feature-task misalignment, and biased imputation—and show that these ambiguities can alter model signals without affecting overall predictive performance. They provide practical recommendations and open-source code for more temporally valid, clinically aligned, and reproducible preprocessing.

By Carolin Ciss\'ee, Dennis Fast, Raneen Younis, Alexander L\"oser, Wolfgang Nejdl, Zahra Ahmadi