TracingFlow: A Simulation-Free Trajectory Inference Framework Based on Second-Order Dynamics
Read the original on arXiv AI →The Flow has not summarised this story yet — read it at arXiv AI.
The Flow has not summarised this story yet — read it at arXiv AI.
arXiv:2510.01159v3 Announce Type: replace Abstract: Learning the dynamics of a process given sampled observations at several time points is an important but difficult task in many scientific applicat...
arXiv:2607. 26398v1 Announce Type: new Abstract: Diffusion and flow-based models benefit from simple regression losses, but inference incurs significant overhead because sampling requires integration.
The paper introduces SUDO, a simulation‑free framework for unbalanced dynamic optimal transport (UDOT) that supports general convex growth penalties beyond the quadratic Wasserstein‑Fisher‑Rao case. By showing that concave penalties lead to degenerate solutions, the authors focus on convex penalties, learning conditional paths and transport costs to solve a semi‑coupling problem and then applying unbalanced flow matching. On benchmark datasets, SUDO matches the accuracy of analytical WFR solvers while being faster than simulation‑based methods, and it also handles asymmetric penalties that better reflect proliferation‑dominant biological priors.
The paper introduces the Variational Incompressible Optimal Transport (VIOT) operator, a generative neural operator that predicts divergence‑free velocity fields for incompressible density transport. VIOT combines a stream‑function representation, a regularized transport objective, and a Fourier Neural Operator backbone to amortize the solve across new source‑target pairs and grid resolutions. Experiments on 2D and 3D benchmarks show that VIOT produces full transport trajectories in seconds, achieving roughly a $10^4 imes$ speedup over per‑instance baselines that require hours of optimization.
arXiv:2506. 22228v2 Announce Type: replace-cross Abstract: Single-cell sequencing is revolutionizing biology by enabling detailed investigations of cell-state transitions.
The paper introduces a new framework for learning continuous-time diffeomorphic image registration by modeling a non-autonomous ODE as a two-parameter flow map. By enforcing cocycle consistency, the method learns flow maps without time discretization or velocity integration during training, enabling efficient inference with few compositions. Experiments on nine datasets show consistent alignment improvements, including a 2.1% Dice gain on brain MRI, 12% TRE reduction on lung CT, and 2.6% Dice improvement on cardiac MRI and ultrasound.