The article proposes a framework called quantitative evidence mining to transform biomedical findings into structured, context-rich evidence units. It outlines core elements such as claim, measured entity, value, comparator, population, conditions, temporal context, uncertainty, provenance, validation, and expert review. The authors present an eight-stage reference architecture and emphasize that plausibility should remain multidimensional rather than collapsed into a single truth label, linking extraction to evidence synthesis for applications like clinical trials, biomarker research, and knowledge-graph construction.
By Negin Sadat Babaiha, Stefan Geissler, Marie-Christine Simon, Martin Hofmann-Apitius, Marc Jacobs
arXiv:2606. 05436v1 Announce Type: new Abstract: Summarizing the latest medical literature to guide clinical decision-making is essential for evidence-based medicine and high-quality patient care.
By Alejandro Lozano, Keiko Ihara, Ping-Hao Yang, Carrie E. Robertson, Jennifer Stern, Allan Purdy, Hsiangkuo Yuan, Pengfei Zhang, Yulia Orlova, Olga Fermo, Jennifer Hranilovich, Fred Cohen, Todd J. Schwedt, Jenelle A. Jindal, Serena Yeung-Levy, Chia-Chun Chiang
arXiv:2610.01938v1 Announce Type: cross
Abstract: Exam-style accuracy does not establish whether large language models (LLMs) reason well over clinical records. We define clinical reasoning as integr...
By Zhangshu Joshua Jiang, Zina Ibrahim, James T. Teo
arXiv:2608.30393v1 Announce Type: new
Abstract: Biomedical artificial intelligence (AI) systems increasingly extract, organize, and reuse scientific claims from literature, clinical trials, and regul...
By Negin Sadat Babaiha, Stefan Geissler, Marie-Christine Simon, Martin Hofmann-Apitius, Marc Jacobs
arXiv:2607. 19201v1 Announce Type: cross Abstract: Clinical NLP evaluation remains dominated by multiple-choice question answering (MCQA), which scores only final-answer accuracy and cannot detect when a model reaches the correct diagnosis while grounding it in irrelevant, absent, or contradictory evidence.
By Iker De la Iglesia, Johanna Ramirez-Romero, Jose Maria Villa-Gonzalez, Irune Urroz Garc\'ia, Ander Barrena, Aitziber Atutxa
The paper introduces CLEAR, an agentic framework designed to improve the reliability of large language models (LLMs) in medical contexts by adjudicating evidence from multiple sources. CLEAR generates candidate answers from three distinct pathways—parametric knowledge, locally curated corpora, and dynamically retrieved evidence—and then uses an aggregation verifier to evaluate agreement and conflict among these sources. An adjudication module decides whether to preserve or revise conclusions, employing override-guard and challenge-audit mechanisms, and initiates targeted follow-up searches when conflicts remain unresolved.
By Shuai Wang, Yize Zhao, Qingyu Chen