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arXiv Machine Learning By Fabian Schneider, Meghdoot Mozumder, Konstantin Tamarov, Leila Taghizadeh, Tanja Tarvainen, Tapio Helin, Duc-Lam Duong

Score-based diffusion models for severely ill-posed problems in diffuse optical tomography

Read the original on arXiv Machine Learning →

Score-based diffusion models, a recent framework for posterior sampling in Bayesian inverse problems, are applied to diffuse optical tomography (DOT), a highly ill‑posed boundary value problem for recovering tissue absorption and scattering. The authors introduce a mixed score that combines a learned component with a model‑based component, providing a theoretical justification for its local approximation to the true score in the small diffusion‑time regime. Four difference‑imaging approaches are compared—classical model‑based, approximate diffusion, exact posterior sampling (UCoS), and a regularized UCoS—showing that UCoS yields more accurate reconstructions, especially under limited‑view geometry and real experimental data.

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