arXiv AI
RegDivergence-101: An LLM Benchmark for Cross-Jurisdiction Regulatory Contradiction Detection in Life Sciences
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arXiv AI
Jun 11
BioDivergence: A Benchmark and Evaluation Framework for Hidden Contextual Contradictions in Biomedical Abstracts
arXiv:2606. 11208v1 Announce Type: cross Abstract: Biomedical findings often seem to conflict across studies, but many of these differences are context-dependent rather than true contradictions.
arXiv Computation and Language
Sep 23
Quantitative Evidence Mining for Plausibility-Aware Biomedical AI: A Narrative Review and Conceptual Framework
The article proposes a framework called quantitative evidence mining to transform biomedical findings into structured, context-rich evidence units. It outlines core elements such as claim, measured entity, value, comparator, population, conditions, temporal context, uncertainty, provenance, validation, and expert review. The authors present an eight-stage reference architecture and emphasize that plausibility should remain multidimensional rather than collapsed into a single truth label, linking extraction to evidence synthesis for applications like clinical trials, biomarker research, and knowledge-graph construction.
arXiv Computation and Language
Sep 25
Clinical Intent Extraction: A FHIR-Aligned Representation and the CIRCA Benchmark
The paper introduces Clinical Intent Extraction (CIE), a task that transforms fragmented clinical action annotations into complete structured records called Clinical Intent Representation (CIR). CIR decomposes each action into verb, type, coded target, timing, condition, request‑intent (aligned to HL7 FHIR) and modality, adding dimensions absent in prior datasets. By re‑expressing five heterogeneous corpora into CIR, the authors create CIRCA, a benchmark of 10,011 harmonized intents with human‑validated subsets, crosswalks, and a deterministic FHIR R4 mapper, and demonstrate that existing models perform poorly on the full task, highlighting the need for targeted development.
arXiv Computation and Language
Sep 21
TrialAtlas: Multi-Agent Research Organization for Clinical Trial Design and Optimization
arXiv:2609.21859v1 Announce Type: new Abstract: Nearly 90% of drugs entering clinical development ultimately fail, despite billions of dollars in investment. Pharmaceutical companies therefore rely o...
arXiv AI
Jun 30
From Regulatory Approvals to Patents: Cross-Domain Linking for Cardiovascular Device Traceability
arXiv:2606. 28353v1 Announce Type: cross Abstract: Linking FDA-approved medical devices to their underlying United States Patent and Trademark Office (USPTO) patents enables critical applications such as recall root-cause analysis, M&A-driven IP discovery, and technology trajectory mapping.
arXiv AI
Aug 17
A Four-Axis Trustworthiness Benchmark for LLM-as-Judge in Principle-Based Regulation
arXiv:2608. 14329v1 Announce Type: cross Abstract: Principle-based regulation, with evaluative standards such as "fair, clear, and not misleading" or "deliver good outcomes", cannot be reduced to binary predicates, and LLM-as-judge is increasingly used as the substitute.