arXiv AI By Andrea Agostini, Simon B\"ohi, Moritz Vandenhirtz, Samuel Ruiperez-Campillo, Max Kr\"ahenmann, Silke M\"uhlstedt, Irene Cannistraci, Ece \"Ozkan Elsen, Julia E. Vogt, Thomas M. Sutter

Reading the Whole Heart: Latent-Attention Masked Autoencoders for Multimodal Cardiac Representation Learning

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The paper introduces Latent-Attention Masked Autoencoder (LAMAE), a multimodal masked autoencoder that learns patient-level representations by exchanging information directly in the latent space through a shared latent-attention module. LAMAE integrates complementary modalities—electrocardiogram, echocardiography, and chest X-rays—within a study-view-entity hierarchy, enabling aggregation of variable observations and handling missing modalities. Pretraining on over 500,000 MIMIC-IV hospital stays, LAMAE outperforms modality-specific pretraining and strong contrastive and vision-language baselines on multimodal hospital-stay tasks such as in-hospital mortality, ICD-10 and DRG coding, and length of stay, while remaining competitive on unimodal tasks.

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