arXiv AI October 7, 2026 By Milad Mohammadi, Fatemeh Akrami Shamsabadi, Zahra Mohseni, Amirhossein Safdarian, Malekfarhad Malek, Hadi Moradi, Hesham Faili

PsyCIDRA: A Dual-Agent Framework for Psychiatric Interviewing and Diagnostic Reasoning

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PsyCIDRA is a dual‑agent framework that couples a free‑form psychiatric interviewer with a diagnostic reasoning agent to support expert review. The interviewer agent uses tools to keep working notes, load expert skills, and pull ICD‑11 references, while the diagnostic agent receives the interview transcript and generates hypotheses with supporting, conflicting, and missing evidence, withholding a final hypothesis if insufficient support exists. In simulations and a blinded human study, PsyCIDRA achieved higher diagnostic agreement and rank‑1 accuracy than direct prompting, indicating its promise for assisting psychiatric assessment through interactive dialogue.

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