The paper reviews how large language models are applied in mental health, covering areas such as social media analysis, clinical conversational agents, therapy support tools, prompt engineering, and multimodal learning. It synthesizes interdisciplinary studies that use social media posts, electronic medical records, and multimodal inputs to detect depression, assess suicide risk, provide personalized therapy, and generate psychoeducational content. The review also discusses advances in model interpretability, annotation strategies, multimodal fusion techniques, and highlights ethical, sociotechnical, and regulatory challenges while proposing frameworks for safe, equitable, and accountable deployment.
By Yisong Chen, Yifan Gao, Sijing Yu, Chuqing Zhao, Yang Lu
arXiv:2607.23648v2 Announce Type: replace
Abstract: Using large language models (LLMs) to assist psychological counseling is an important task in the field of natural language processing. The constru...
By Kaitong Weng, Lixin Liu, Zihao Liu, Bo Wang, Shiguang Ni
The paper introduces a domain‑specific Constitutional AI framework designed to improve safety in large‑language‑model‑powered mental health chatbots. It highlights the unique risks of mental‑health applications—such as misdiagnosis, symptom exacerbation, and self‑harm—and argues that general AI safeguards are insufficient for these sensitive contexts. The authors propose training models with mental‑health‑specific principles to ensure accurate crisis intervention, adherence to therapeutic guidelines, and robust handling of nuanced, vulnerable dialogues.
By Chenhan Lyu, Yutong Song, Pengfei Zhang, Amir M. Rahmani
arXiv:2606. 10380v1 Announce Type: cross Abstract: Real-world crisis intervention is inherently conversational, yet existing research largely focuses on static texts.
By Grace Byun, Abigail Lott, Rebecca Lipschutz, Sean T. Minton, Elizabeth A. Stinson, Jinho D. Choi
MindEval2 is a new evaluation framework for AI chatbots in mental health support, comprising Mental Health Quality Rubrics (MHQR) and the MindSim patient simulation harness. MHQR, developed with PhD-level psychologists, provides explicit, actionable criteria for assessing response quality, while MindSim offers realistic, longitudinal patient interactions with a memory component. The study evaluated 18 models, finding that although surface-level quality has improved, guidance calibration remains the main failure across all models.
By John Mendon\c{c}a, Daniel Tschernutter, Jos\'e Pombal, Areti Vassilopoulos, Catarina Botelho, Ignacio Sarasua, Maya D'Eon, Nuno Guerreiro, Ricardo Rei
The article surveys how large language models (LLMs) are being applied to mental health, outlining a three‑phase evolution: Phase I uses LLMs as passive information tools and pattern recognizers for assessment; Phase II employs them as empathetic conversationalists for stateless, in‑the‑moment interactions; Phase III aims to create longitudinal, personalized companions that act as stateful cognitive agents. It systematically reviews core technologies, agent architectures (Profile, Memory, Reasoning, Planning), and the datasets and benchmarks that support this progression, offering a coherent narrative and roadmap for future research. The survey also provides a curated resource list at https://github.com/Emo-gml/Awesome-Mental-Health-LLMs.
By He Hu, Yucheng Zhou, Qianning Wang, Yingjian Zou, Chiyuan Ma, Juzheng Si, Jianzhuang Liu, Zitong Yu, Laizhong Cui, Fei Ma, Qi Tian