Hugging Face Trending Papers
Jun 17

Be Your Own Teacher: Steering Protein Language Models via Unsupervised Reward Optimization

Protein language models (PLMs) have emerged as powerful tools for controllable biomolecular design, yet their post-training adaptation typically relies on costly wet-lab validation or curated preference datasets. To overcome this supervision bottleneck, we introduce unsupervised reward optimization of PLMs, a comprehensive framework for steerable protein generation without ground-truth labels.

arXiv AI
Sep 1

Personalized Group Relative Policy Optimization for Heterogenous Preference Alignment

The paper introduces Personalized Group Relative Policy Optimization (P‑GRPO), a new alignment framework for large language models that separates advantage estimation from immediate batch statistics. By normalizing advantages using preference‑group‑specific reward histories instead of the concurrent generation group, P‑GRPO maintains contrastive signals for distinct user preferences. Experiments across various tasks show that P‑GRPO converges faster and yields higher rewards than standard GRPO, improving alignment with heterogeneous human preferences while preserving general capabilities.

By Jialu Wang, Heinrich Peters, Asad A. Butt, Navid Hashemi, Alireza Hashemi, Pouya M. Ghari, Joseph Hoover, James Rae, Morteza Dehghani