Hugging Face Trending Papers June 17, 2026

Be Your Own Teacher: Steering Protein Language Models via Unsupervised Reward Optimization

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Protein language models (PLMs) have emerged as powerful tools for controllable biomolecular design, yet their post-training adaptation typically relies on costly wet-lab validation or curated preference datasets. To overcome this supervision bottleneck, we introduce unsupervised reward optimization of PLMs, a comprehensive framework for steerable protein generation without ground-truth labels.

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