arXiv Machine Learning
Aug 24

PerturbRx: Learning Treatment-Conditioned Latent Transitions for Patient Drug Response Prediction

PerturbRx is a treatment‑conditioned representation learning framework that learns latent transitions induced by drug interventions. It trains a drug‑ and dose‑conditioned transition predictor using control and treated single‑cell populations, then applies this predictor to pretreatment patient profiles to generate response features without needing post‑treatment data. On TCGA and patient‑derived xenograft benchmarks, PerturbRx outperforms other methods, demonstrating the value of perturbation‑pretrained latent transitions for patient‑level drug‑response prediction.

By Yoshitaka Inoue, Minoh Jeong, Alfred Hero, Rui Kuang, Augustin Luna
arXiv Machine Learning
Jul 30

Challenges and proposed solutions in modeling multimodal medical data: A systematic review

arXiv:2505. 06945v5 Announce Type: replace Abstract: Multimodal data modeling has emerged as a powerful approach in clinical research, enabling the integration of diverse data types such as imaging, genomics, wearable sensors, and electronic health records.

By Maryam Farhadizadeh, Maria Weymann, Michael Bla{\ss}, Johann Kraus, Christopher Gundler, Sebastian Walter, Noah Hempen, Hannah Bast, Harald Binder, Nadine Binder
arXiv Computer Vision
Aug 21

MOSAIC: Modality-agnostic Spectral Alignment for Federated Image-level Weakly Supervised Tumor Segmentation under Client-specific Missing Modalities

arXiv:2608. 19788v1 Announce Type: cross Abstract: Trustworthy multimodal fusion in clinical settings requires handling incomplete and heterogeneous modality subsets across institutions, where privacy constraints prohibit centralized data sharing.

By Tarun Kumar Garg, Vaanathi Sundaresan