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Multipath Adaptive Gated Bottleneck Latent ODE with Raman Data Fusion for Cell Culture Process Forecasting

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Mammalian cell-culture processes underpin the manufacture of many biopharmaceuticals, yet keeping a run on track is hard: critical process parameters drift over days, and an off-specification trend is often confirmed too late to intervene. Early-stage, multi-day forecasts could enable timely adjustment of feeding, sampling, and control, but bioprocess forecasting is challenging because measurements are sparse and irregularly sampled, operating conditions are heterogeneous across cell lines and media, and runs with near-identical early behaviour can diverge into different futures.

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arXiv AI
Jun 26

Multipath Adaptive Gated Bottleneck Latent ODE with Raman Data Fusion for Cell Culture Process Forecasting

arXiv:2606. 26520v1 Announce Type: cross Abstract: Mammalian cell-culture processes underpin the manufacture of many biopharmaceuticals, yet keeping a run on track is hard: critical process parameters drift over days, and an off-specification trend is often confirmed too late to intervene.

By Johnny Peng, Thanh Tung Khuat, Ellen Otte, Katarzyna Musial, Bogdan Gabrys
arXiv Machine Learning
Aug 7

Kastor: An efficient fine-tuning strategy for generative emulation of PDE simulations

arXiv:2608. 06107v1 Announce Type: new Abstract: Machine learning offers a promising avenue to accelerate physical simulations by replacing computationally expensive traditional Partial Differential Equation (PDE) solvers with fast, differentiable surrogate models.

By Guillaume Couairon, Alexis Jacq, Yu-Han Wu, Renu Singh, Yana Hasson, Quentin Berthet, Romuald Elie
arXiv Machine Learning
Sep 25

Beyond Compression: Training Latent Representations for Stable Long-Horizon Rollout in Neural Surrogate Solvers

The paper investigates why latent neural surrogate solvers, which compress physical system dynamics into a lower‑dimensional space, often fail during long‑horizon autoregressive rollouts. It demonstrates that training the latent representation only for reconstruction leads to instability, and proposes a set of training interventions—Koopman operator learning, Hamming noise injection, and multi‑step rollout fine‑tuning—that align the latent space with long‑horizon forecasting. These interventions reduce long‑rollout error by about 40 % and achieve accuracy comparable to full‑resolution models while using far fewer floating‑point operations and GPU memory, enabling stable extrapolation in mesoscale crystal‑plasticity simulations of high‑cycle fatigue.

By Andreas E. Robertson, Ashley T. Lenau, John D. Shimanek, Benjamin A. Jasperson, Vivek Oommen, David L. Damm, Krishna Garikipati, Remi Dingreville
arXiv Machine Learning
Jun 5

REGEN: Reference-Guided Synthetic Multivariate Time Series Generation for Forecasting

arXiv:2606. 05264v1 Announce Type: new Abstract: Training robust multivariate time series forecasting models requires large, diverse corpora, yet many real-world domains provide only a handful of observed sequences.

By Moulik Gupta (Birla AI Labs), Dhruv Kumar (Birla AI Labs, Birla Institute of Technology and Science, Pilani), Murari Mandal (Birla AI Labs, Kalinga Institute of Industrial Technology), Saurabh Deshpande (Birla AI Labs)