arXiv AI By Nian Ran, Zhongzheng Li, Yue Wang, Qingsong Ran, Xiaoyuan Zhang, Shikun Feng, Richard Allmendinger, Xiaoguang Zhao

MCCE: A Framework for Multi-LLM Collaborative Search in Discrete Spaces with Similarity-Filtered Preference Learning

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The paper introduces MCCE, a hybrid framework that combines a frozen closed‑source large language model (LLM) with a lightweight, trainable model for multi‑objective discrete optimization. By maintaining a trajectory memory and refining the small model through reinforcement learning, the two models jointly enhance global exploration and learning. Experiments on drug‑design benchmarks demonstrate that MCCE achieves state‑of‑the‑art Pareto front quality, outperforming existing baselines.

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