arXiv Machine Learning By Fangzhou Wang, Yixuan Yang, Camilla Balzarotti, Rishikesan Kamaleswaran

Intervention Granularity Matters: Coherent Treatment Bundles in Counterfactual Simulation with Clinical World Models

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The paper investigates how the granularity of interventions—single components versus full treatment bundles—affects counterfactual simulations using a clinical world model. By analyzing 945,707 patient-hours from MIMIC-IV, the authors show that interventions are naturally bundled, and editing a single component often represents an unreal scenario. Experiments with Clin‑JEPA on 1,019 ventilation onsets demonstrate that editing the complete bundle produces larger predicted state changes than editing individual settings, indicating that bundle-aware editing better captures treatment sensitivity.

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