The article explores how biological learning and decision-making, often modeled as Bayesian processes, can be replicated in computing systems by leveraging noisy neural and synaptic dynamics for stochastic sampling. It proposes a biologically grounded framework where internal energy functions capture uncertainty over latent states and model parameters, enabling predictive coding networks to perform Markov chain Monte Carlo sampling. By drawing parallels between intrinsic biological noise and electrical noise in emerging probabilistic analogue memory technologies, the authors argue that analogue in‑memory computing hardware offers a massively scalable and energy‑efficient solution for probabilistic inference.
By Thomas Dalgaty, Eiji Kawasaki, Miguel de Prado, Devendra Vyas, Tommaso Salvatori
arXiv:2608.25631v1 Announce Type: cross
Abstract: Continuous-time Markov chains (CTMCs) provide the backbone for modeling discrete stochastic dynamics across applied, physical, and biological science...
By Jose M. G. Vilar, Leonor Saiz
arXiv:2510.16656v2 Announce Type: replace
Abstract: Modeling dynamical systems and unraveling their underlying structural dependencies is central to many domains in the natural sciences. Various phys...
By Noah El Rimawi-Fine, Adam Stecklov, Lucas Nelson, Mathieu Blanchette, Alexander Tong, Stephen Y. Zhang, Lazar Atanackovic
arXiv:2608. 13800v1 Announce Type: new Abstract: Transition path sampling (TPS) aims to efficiently generate rare molecular transition trajectories between metastable states and is essential for understanding biomolecular mechanisms.
By Jingqian Liu, Yu-Hsiang Wang, Yanru Qu, Ge Liu
arXiv:2606. 24990v1 Announce Type: new Abstract: Reinforcement Learning (RL) has become a powerful paradigm for de novo molecular design, enabling Chemical Language Models (CLMs) to navigate and explore the chemical space while optimizing specific desired properties.
By Borja Medina, Jon Paul Janet
arXiv:2604. 13213v2 Announce Type: replace-cross Abstract: Rare events such as conformational changes in biomolecules, phase transitions, and chemical reactions are central to the behavior of many physical systems, yet they are extremely difficult to study computationally because unbiased simulations seldom produce them.
By Yuanqi Du, Jiajun He, Dinghuai Zhang, Eric Vanden-Eijnden, Carles Domingo-Enrich