arXiv:2606. 08191v1 Announce Type: cross Abstract: Token aggregation is a common bottleneck in models that map token representations to sample-level predictions, yet most pooling methods operate only in the original token domain.
By Kewei Li, Rongying Zhang, Xueli Wang, Xiwen Gong, Zhongjian Wang, Lan Huang, Ruochi Zhang, Fengfeng Zhou
The study demonstrates that a simple, sequence-only approach using 330 interpretable descriptors and the TabPFN tabular foundation model can outperform complex multimodal deep learning methods for multi-label antimicrobial peptide activity prediction. On the ESCAPE benchmark (82,359 peptides, five labels), a label‑powerset TabPFN model achieved a mean average precision of 77.8%, surpassing the previous best of 72.1%. The approach also shows that predicted structure is unnecessary, that a small set of global physicochemical scalars can recover most performance, and that modeling label dependence benefits rare activities and informs assay prioritization.
By Raunak Kumar, Anuj Pal, Dhruvi Solanki, Parikshit Pareek, Juhi Singh, Jitin Singla
GyroNovo is a new framework for de novo peptide sequencing that improves fragment imputation by guiding the process with decoder errors observed during training. It introduces mass-aware attention using rotary embeddings to encode pairwise mass differences between spectral peaks, and creates easy and hard augmented views of spectra to train the decoder under varying corruption levels. Experiments on NovoBench demonstrate significant gains, with about 9 percentage points higher peptide-level precision and 7 percentage points higher amino-acid-level precision compared to the state-of-the-art baseline.
By Abdellah El Mekki, Laks V. S. Lakshmanan, Muhammad Abdul-Mageed
Freeze, Diffuse, Decode (FDD) is a diffusion-based framework that adapts pre‑trained transformer embeddings to downstream tasks while preserving their geometric structure. By propagating supervised signals along the intrinsic manifold of frozen embeddings, FDD produces low‑dimensional, predictive, and interpretable representations. In antimicrobial peptide design, these representations support property prediction, retrieval, and latent‑space interpolation.
By Pankhil Gawade, Adam Izdebski, Myriam Lizotte, Kevin R. Moon, Jake S. Rhodes, Guy Wolf, Ewa Szczurek
Antimicrobial peptides (AMPs) often act against multiple pathogen classes, making multi-label activity prediction a more realistic screening target than binary antimicrobial classification. The ESCAPE...
arXiv:2607. 15047v1 Announce Type: cross Abstract: Mild Cognitive Impairment is a critical early stage of cognitive decline that frequently precedes Alzheimer's disease, yet its automated detection from neuropsychological drawing tests remains fundamentally constrained by data scarcity, class imbalance, and diagnostic ambiguity near clinical boundaries.
By Javad Khoramdel, Farhad Hoseyni, Amirhossein Nikoofard