arXiv:2608.28974v1 Announce Type: new
Abstract: Clinically relevant oncology information is distributed across heterogeneous, longitudinal documentation, creating substantial abstraction burden and r...
By Daniel Kang, Michelle Hu, Soorya Ram Shimgekar, Shayan Vassef, Yufan Wang, Anit Kumar Sahu, Munmun De Choudhury, Vedant Das Swain, Christian Poellabauer, Li Yan Khor, Koustuv Saha, Robert Wojciechowski, Elliot Kidd, Piyum Zonooz, Navin Kumar
The paper introduces VERGE, a verification-enhanced refinement workflow that extracts six red‑flag symptoms and family‑history risk status for early‑onset colorectal cancer from free‑text clinical notes. VERGE uses retrieval‑augmented generation followed by a bounded verification‑refinement cycle that checks textual grounding and clinical validity, correcting claims until resolved or escalating to human review. In evaluation on 4,033 clinician‑labeled note‑finding pairs, VERGE improved precision from 0.764 to 0.849 and MCC from 0.681 to 0.730 compared to a single‑agent baseline, while requiring human review for only 1.5 % of claims.
By Nikkie Hooman, Monarch Nigam, Amy E. Hughes, Rasmi G. Nair, Mehak Gupta
arXiv:2607. 12886v1 Announce Type: new Abstract: Clinical notes contain many of the signs and symptoms that bring patients to care, yet this information rarely reaches structured fields.
By Cameron Cagan, Pedram Fard, Jiazi Tian, Jingya Cheng, Shawn N. Murphy, Hossein Estiri
The paper introduces ClinGeX, a large‑language‑model agent that uses 105 curated executable skills to automate clinical genomic analysis. In benchmark tests, ClinGeX achieved 71.7% macro‑averaged task‑level concordance, outperforming the best comparator at 45.7%. Human‑AI collaboration studies showed ClinGeX significantly improved case‑level concordance across variant analysis, rare disease interpretation, and oncology decision‑making, while also reducing interpretation time.
By Qiaoyu Zheng, Weike Zhao, Yanjie Fan, Ye Cao, Mengqi Jiang, Xiao Zhou, Xiaoman Zhang, Pengcheng Qiu, Yongguo Yu, Yanfeng Wang, Ya Zhang, Chaoyi Wu, Weidi Xie
arXiv:2603. 01131v3 Announce Type: replace-cross Abstract: Clinical diagnosis is a gradual process of evidence integration, in which physicians move from symptoms and medical history to examinations, competing hypotheses, disease relations, and treatment decisions.
By Yuqi Zhan, Xinyue Wu, Tianyu Lin, Yutong Bao, Xiaoyu Wang, Weihao Cheng, Huangwei Chen, Feiwei Qin, Zhu Zhu
LUCAID is an agentic multimodal AI system designed for precision lung cancer pathology, integrating nine modules that cover the entire routine workflow—from quality control and tumor detection to histological subtyping, microenvironment profiling, cellularity quantification, and biomarker scoring (PD‑L1, MET, TROP‑2). The system generates automated structured reports and allows interactive querying of module outputs. In prospective clinical validation, LUCAID achieved 93.0% concordance with an expert‑panel reference standard for clinically actionable decisions, outperforming five experienced thoracic pathologists who ranged from 68.3% to 81.1% concordance.
By Marie-Lisa Eich, Kai Standvoss, Timo Milbich, Alexander M\"ollers, Miriam H\"agele, Philipp Anders, Lars Tharun, Hanna Kontradiuk, Sebastian Kons, Nader Aldoj, Recepcan Adig\"uzel, Adam Narai, Lukas H\"onig, Jonathan Striebel, Binru Yang, Mihnea P. Dragomir, Marvin Sextro, Philipp Keyl, Philipp Jurmeister, Rosemarie Krupar, Evelyn Ramberger, James Wells, Julika Ribbat-Idel, Andreas Kunft, Hussam Shuaib, Christian Groh\'e, Reinhard B\"uttner, David Horst, Klaus-Robert M\"uller, Lukas Ruff, Maximilian Alber, Frederick Klauschen, Simon Schallenberg