The paper introduces FCA‑Guided Counterfactual (FCA‑CF) explanations for multi‑modal breast cancer diagnosis, leveraging a Formal Concept Analysis lattice as a hard structural constraint to generate counterfactuals. On the TCGA‑BRCA dataset, FCA‑CF achieves perfect validity (100% prediction flips), the lowest average feature changes (2.37), and competitive proximity (0.900), outperforming four established counterfactual methods. Ablation studies show the lattice constraint and a greedy refinement phase are key to its sparsity and validity.
arXiv:2601. 14590v3 Announce Type: replace Abstract: Counterfactual explanations (CFEs) provide human-centric interpretability by identifying the minimal, actionable changes required to alter a machine learning model's prediction.
By Shovito Barua Soumma, Asiful Arefeen, Stephanie M. Carpenter, Melanie Hingle, Hassan Ghasemzadeh
arXiv:2608. 03079v1 Announce Type: cross Abstract: Breast core needle biopsy (CNB) is central to breast cancer diagnosis yet remains challenging because limited tissue sampling, lesion heterogeneity, and subtle morphologic overlap can obscure subtype distinctions.
By Ting Yin, Danning Li, Chen Shu, Xiaoxia Yao, Boyu Fu, Yujing Chang, Tianyu Shi, Mengna Feng, Jie Chen, Jing Fu, Xiuli Xiao, Tianlin Li, Mumin Shao, Jiaxin Bi, Wenchuan Zhang, Xiaoyan Wu, Xiao Han, Zhang Zhang, Yuhao Yi, Hong Bu
In a UK multicentre trial, an unconstrained XGBoost model incorrectly learned that higher tumour stage and carcinoma in situ predicted lower bladder cancer recurrence risk, a finding that conventional metrics such as discrimination, calibration, and SHAP failed to detect. The authors introduced a counterfactual direction test and a monotonic‑constraint framework, which removed the inversion without harming model performance and even outperformed established risk systems. The study demonstrates that such tests should be routine before deploying predictive models in clinical settings.
By Saram Abbas, David Thomas, Naeem Soomro, Rishad Shafik, Rakesh Heer, Kabita Adhikari
arXiv:2605.07785v3 Announce Type: replace
Abstract: Concept Bottleneck Models (CBMs) in medical imaging aim to improve model interpretability by predicting intermediate clinical concepts before final...
By Amy Rafferty, Rishi Ramaesh, Ajitha Rajan
arXiv:2608. 00076v2 Announce Type: replace-cross Abstract: Multimodal large language models (MLLMs) increasingly support high-stakes decision making by combining complementary information from images and text.
By Vahidin Hasic, Chao Wang, Luis C. Garcia-Peraza-Herrera, David Watson, Senka Krivic