Hepatitis C is a liver infection caused by a virus, which results in mild to severe inflammation of the liver. Over many years, hepatitis C gradually damages the liver, often leading to permanent scarring, known as cirrhosis.
arXiv:2601.00175v3 Announce Type: replace
Abstract: Objective: Develop and evaluate machine learning (ML) models for predicting incident liver cirrhosis (LC) one and two years before diagnosis using...
By Zhuqi Miao, Ahmed G Qasem, Sujan Ravi, Jason T. Cheng, Abdulaziz Ahmed, Courtney W. Houchen, Sumayah Abed, Dilorom Azimdjanovna Zuparova, Abdulaziz Ahmed
arXiv:2601. 00175v2 Announce Type: replace Abstract: Objective: Develop and evaluate machine learning (ML) models for predicting incident liver cirrhosis (LC) one and two years prior to diagnosis using routinely collected electronic health record (EHR) data and benchmark their performance against the FIB-4 and APRI clinical scores.
By Zhuqi Miao, Ahmed G Qasem, Sujan Ravi, Jason T. Cheng, Abdulaziz Ahmed, Courtney W. Houchen, Sumayah Abed, Dilorom Azimdjanovna Zuparova, Abdulaziz Ahmed
This study investigates deep learning and explainable AI methods to diagnose hepatocellular carcinoma (HCC) and identify diagnostic and prognostic biomarkers across five disease stages using a transcriptomic dataset built via semi‑supervised learning. The best model used 15 genes selected by SelectKBest, achieving 90.74% accuracy, while a 20‑gene model had the lowest loss of 0.3187. SHAP‑based XAI highlighted DNAJB14 as the most influential gene, and functional validation showed that inhibiting DNAJB14 reverses key malignant traits of HCC cells.
By Ali Bou Nassif, Darko Castven, Manar Abu Talib, Jibran Sualeh Muhammad, Ahmed Ammar Kubba, Jens Marquardt, Abdalla Sayed Ali
arXiv:2606. 09860v1 Announce Type: cross Abstract: Non-alcoholic fatty liver disease (NAFLD) affects roughly 25% of global adults, posing substantial hepatic and cardiovascular risks.
By Xinze Zhang
arXiv:2607. 00472v1 Announce Type: cross Abstract: Cardiovascular disease is still one of the main causes of death around the world.
By Sagnik Ghosh