arXiv AI August 12, 2026 By Dong Xu, Zhangfan Yang, Jiantao Wu, Zexuan Zhu, Jianqiang Li, Junkai Ji

DegradeQuery: Counterfactual Tuple Pretraining for Context-Aware PROTAC Degradation Prediction

arXiv:2608. 10595v1 Announce Type: cross Abstract: Proteolysis-targeting chimeras (PROTACs) induce protein degradation by recruiting a target protein to an E3 ubiquitin ligase, making degradation a joint outcome of the degrader molecule and its biological context.

Summary generated by The Flow from the publisher's feed. The full article lives at arXiv AI.

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DegradeQuery: Counterfactual Tuple Pretraining for Context-Aware PROTAC Degradation Prediction

Proteolysis-targeting chimeras (PROTACs) induce protein degradation by recruiting a target protein to an E3 ubiquitin ligase, making degradation a joint outcome of the degrader molecule and its biological context. Although public databases contain thousands of structured molecule-target-E3 records, degradation measurements are available for only a small fraction of them.

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DegradeQuery: Counterfactual Tuple Pretraining for Context-Aware PROTAC Degradation Prediction

Structure-Aware Prediction of PROTAC-Mediated Protein Degradability via Graph Neural Networks

Can Tabular In-Context Learners Generalize to Biomolecular Property Prediction?

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