arXiv:2606. 02605v1 Announce Type: cross Abstract: Coronary artery stenosis is a common cardiovascular disease, with severe, untreated cases posing significant risks of heart attack.
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A multicenter study developed an AI-enabled electrocardiography (AI-ECG) model that predicts vessel-specific hemodynamically significant stenosis using coronary computed tomographic angiography (CCTA) as the reference. The model demonstrated strong discrimination in internal and external cohorts, including normal ECGs, and produced low-, intermediate-, and high-risk strata that correlated with stenosis severity and major adverse cardiovascular events. Calibration, decision curve analyses, and integration with guideline-based pre-test probability showed clinical utility, while waveform and attribution analyses revealed physiologically meaningful ECG features linked to high-risk predictions.
The study demonstrates that contrastive pre‑training of ECG representations using cardiac magnetic resonance (CMR) imaging data can enhance ECG‑based detection of Chagas disease. By aligning an ECG encoder with a CMR embedding space from 63,193 paired UK Biobank examinations, the authors achieved higher AUROC and sensitivity metrics on CODE‑15%, SaMi‑Trop, and PhysioNet/CinC 2025 Challenge datasets compared to an unaligned baseline. The approach shows that imaging‑supervised ECG representations generalize across different populations and resource‑constrained settings.
arXiv:2607. 16323v1 Announce Type: cross Abstract: Electrocardiography (ECG) is an inexpensive, standard-of-care test for cardiac symptoms, but front-line triage often lacks immediate access to definitive imaging such as echocardiography (ECHO) or cardiac magnetic resonance (CMR).
arXiv:2608. 03597v1 Announce Type: new Abstract: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with increased risks of stroke, heart failure, and mortality.
The study investigates whether ECG representations derived from a β-variational autoencoder (VAE) can distinguish patients with myocardial scar (LGE+) from those without (LGE-) using routine ECG data. In a cohort of 300 cardiomyopathic patients, the β-VAE achieved an AUC of 0.577 (sensitivity 0.775) with Gradient Boosting, while the foundation ECGx.AI model reached an AUC of 0.686 with Random Forest. Dynamic Time Warping reconstruction errors differed significantly between classes in most leads and improved classification to an AUC of 0.643 with Logistic Regression, suggesting these errors could serve as markers of scar-related ECG changes.
arXiv:2608. 14723v1 Announce Type: cross Abstract: Reduced left ventricular ejection fraction (LVEF) is frequently asymptomatic and often detected only after advanced heart failure develops.