Copula Adapted Directed Acyclic Graph for Cluster Representation of Biomedical Data

The paper presents Copula Adapted Directed Acyclic Graph (CopDAG), a framework that combines copula models with an ensemble of causal structure discovery methods based on Directed Acyclic Graphs to represent biomedical data. By capturing non‑Gaussian, non‑linear dependencies and stable causal relationships, CopDAG enables clustering of unlabeled biomedical data using K‑means. Across 16 biomedical datasets, CopDAG achieves the highest normalized clustering accuracy and adjusted Rand index among 12 evaluated methods, and it can predict class labels and provide explainable causal visualizations without relying on data annotations.

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