arXiv Machine Learning June 9, 2026 By A Shivram, Aneesh S. Chivukula, Manik Gupta, Sourav Chowdhury

Constraint-Aware Optimization for Robust Protein Stability Prediction

Read the original on arXiv Machine Learning →

arXiv:2606. 08100v1 Announce Type: new Abstract: Multimodal $\Delta\Delta G$ predictors integrating protein language models with inverse-folding representations achieve strong in-distribution accuracy on the Megascale dataset but exhibit limited robustness on out-of-distribution (OOD) proteins, persistent forward-reverse bias on paired-mutation benchmarks, and under-representation of rare stabilizing mutations.

Summary generated by The Flow from the publisher's feed. The full article lives at arXiv Machine Learning.

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