arXiv Machine Learning By Paulo R. Ferreira Jr., Lucas Coutinho Freitas, La\'is dos Santos Gon\c{c}alves, William Borges Domingues, Lucas Petitemberte de Souza, Mariana B. Michalowski, Vinicius F. Campos

A Novel Machine Learning Approach for Central Nervous System Tumor Classification from DNA Methylation

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arXiv:2607. 01307v1 Announce Type: new Abstract: NA methylation profiling has become a powerful approach for central nervous system (CNS) tumor classification, yet important challenges remain regarding cross-cohort transferability, methodological correctness, and robust multiclass evaluation.

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arXiv AI
Sep 10

The Accuracy Paradox: Empirical Diagnostic of Default Decision Thresholds in Multi-Label Enzyme Commission Prediction [With Code]

The study evaluates the use of default decision thresholds (t=0.50) in multi‑label enzyme commission (EC) number prediction across 14,096 compounds and six EC classes. It finds a high mean accuracy of 77.16% but low macro F1 (0.3976) and macro recall (0.3872), indicating severe class‑imbalance issues: majority classes are over‑predicted while minority classes, especially EC6, have zero recall despite reasonable ROC‑AUC. The authors recommend target‑specific threshold tuning and conformal calibration as post‑processing safeguards to expose and correct these hidden errors.

By Bilal Ahmad, Rajed Mehmood
arXiv Machine Learning
Jun 19

Computational Methods and Challenges in Cell-Free DNA Analysis for Multi-Cancer Early Detection

arXiv:2606. 20174v1 Announce Type: new Abstract: Cell-free DNA (cfDNA) is a promising avenue for non-invasive multicancer early detection (MCED), in that, it can enable multiple cancer detection simultaneously from a single blood draw, with particular sensitivity to cancers that currently lack established screening programs.

By Nicko Starkey, Marcin W. Wojewodzic, Krzysztof Rzecki